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NOS2 — SETD2

Text-mined interactions from Literome

Jung et al., Circ Res 2000 (Anoxia...) : We investigated the role of hypoxia inducible factor-1 (HIF-1) on expression of the inducible NOS (iNOS) in myocardial cells in vivo and in vitro ... These results demonstrate that hypoxia causes an increase in iNOS expression in cardiac myocytes and that HIF-1 is essential for the hypoxic regulation of iNOS gene expression
Hierholzer et al., Arch Orthop Trauma Surg 2001 (Reperfusion Injury...) : Induction of iNOS during the ischemic phase of HS may involve the activation of the hypoxia-inducible factor-1 (HIF-1)
Hierholzer et al., Langenbecks Arch Surg 2001 (Inflammation...) : The transcription factor hypoxia-inducible factor-1 (HIF-1) may regulate the induction of iNOS during the ischemic phase of shock
Yang et al., Ann N Y Acad Sci 2002 (Glioblastoma...) : Interestingly, HIF-1 also contributes to iNOS induction under hypoxia ... Expression of iNOS may inhibit HIF-1 activity under hypoxia in C6 glioma cells transfected with a VEGF promoter-driven luciferase gene ... Pretreatment of C6 cells with N-acetyl-l-cysteine (NAC), an antioxidant, nullified the inhibitory effect of iNOS on HIF-1 binding
Matrone et al., J Neurochem 2004 (Brain Ischemia...) : Our results revealed that pMCAO up-regulates iNOS protein in the ischemic core, in the area surrounding the ischemic core and in the hippocampus ipsilateral to the lesion, and that the activation of iNOS expression is mediated by HIF-1
Lucattelli et al., Int J Biochem Cell Biol 2008 (Anoxia...) : The up-regulation of hypoxia-inducible factor-1 (HIF-1) leads to an increased downstream expression of HIF-1 target genes, such as TGFbeta and iNOS
Kannan et al., Am J Physiol Gastrointest Liver Physiol 2011 (Acute Lung Injury...) : Furthermore, partial HIF-1a deficiency prevented the induction of ileal mucosal inducible nitric oxide synthase (iNOS) protein levels after SMAO and iNOS deficiency ameliorated SMAO induced villus injury
Fang Li et al., Brain Res 2012 (Brain Ischemia) : Accordingly, in the primary cortical neuron cultures, silencing of HIF-1a attenuated the accumulation of iNOS and the protective effects of isoflurane post conditioning ... Our results suggest the involvement of HIF-1a in the regulation of iNOS during tolerance against cerebral ischemia induced by isoflurane post conditioning, which provide a mechanistic basis of novel therapeutic strategies for ischemic stroke
Cameron et al., Comp Biochem Physiol A Mol Integr Physiol 2013 : The mRNA levels for hif1a ( hypoxia inducible factor 1a ) in the hearts of hypoxia acclimated fish were significantly enhanced , as was nitric oxide synthase ( nos2 ) and the sulfonylurea receptor regulatory subunit ( sur2, abcc9 )
Melillo et al., J Biol Chem 1997 : We demonstrate that addition of iron sulfate completely abolished DFX or PA induction of HIF-1 binding and iNOS-HRE activation and abrogated IFN-gamma plus either DFX- or PA-induced iNOS expression