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EPHB2 — UCN

Text-mined interactions from Literome

Brar et al., J Biol Chem 2000 (MAP Kinase Signaling System...) : UCN caused rapid phosphorylation of ERK1/2-p42/44 , and PD98059, which blocks the MEK1-ERK1/2-p42/44 cascade, also inhibited the survival promoting effect of UCN
Papadopoulou et al., Mol Endocrinol 2004 : We found that the adenylyl cyclase/PKA pathway has the capacity to markedly decrease UCN induced ERK1/2 activation, and that these effects were due in part to the ability of PKA to phosphorylate the CRH-R1alpha at position Ser ( 301 ) in the third intracellular loop
Brar et al., Endocrinology 2004 : Using Chinese hamster ovary cells stably expressing CRFR1 and CRFR2beta, we show that Ucn-I , Ucn-II and Ucn-III activate ERK1/2-p42 , 44 via CRFR2beta ... CRF and Ucn-I but not Ucn-II or Ucn-III activates ERK1/2-p42 , 44 in Chinese hamster ovary cells stably expressing CRFR1 ... Use of the G ( i ) and G ( o ) protein inhibitor pertussis toxin showed that ERK1/2-p42 , 44 activation by Ucn-I via CRFR1 and CRFR2beta are both G ( i ) and/or G ( o ) protein dependent
Pei et al., Mol Pharmacol 2006 (Multiple Myeloma) : They also suggest a role for Chk1 in UCN-01 induced ERK1/2 activation, implying the existence of a heretofore unrecognized link between Chk1 and ERK1/2 signaling
Punn et al., Mol Endocrinol 2006 : In human embryonic kidney 293 cells overexpressing recombinant CRH-R1alpha, UCN I induced ERK1/2 and p38 MAPK activation was dependent on signaling molecules involved in agonist induced CRH-R1alpha trafficking and endocytosis
Kageyama et al., Mol Cell Endocrinol 2007 : Bisindolylmaleimide partially inhibited the UCN mediated decrease in ERK phosphorylation in A7r5 cells, suggesting that the protein kinase C pathway is partially involved in CRF2 receptor signal transduction
Wu et al., Endocrinology 2007 : Ucn 1 and Ucn 2 stimulated dose dependent cAMP production and ERK1/2 phosphorylation in the esophageal cells, whereas CRF and CRF1 agonist, cortagine, had less potent effects
Huang et al., J Mol Endocrinol 2009 : Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-kappaB activation ... Ucn stimulates activation of ERK and p38 MAP kinases, while both MEK1 and p38 inhibitor block Ucn induced IL-6 release ... Finally, the CRH-R antagonists alpha-helical ( 9-41 ) CRH and astressin-2B completely inhibit Ucn induced IL-6 release, as well as activation of ERK , p38, and NF-kappaB
Yuan et al., Mol Cell Endocrinol 2010 : We discovered that a non-receptor tyrosine kinase, Src, is involved in the urocortin induced activation of ERK1/2 in mouse atrial HL-1 myocytes ... The selective Src family kinase inhibitor, PP2, reduced the urocortin induced phosphorylation of ERK1/2 , and so did the expression of a dominant negative mutant of Src in transfected HL-1 cells
Wu et al., Endocrinology 2011 : CRH and Ucn-1 , but not Ucn-2, stimulated significant ERK1/2 phosphorylation