Gene interactions and pathways from curated databases and text-mining

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MOCOS — PCNA

Text-mined interactions from Literome

Yamamoto et al., Dev Biol 2005 (MAP Kinase Signaling System) : Our results indicate that under CSF arrest, Mos/MAPK activity suppresses cyclin B degradation, preventing Cdc2 activity from falling below normal meta-II levels, whereas activation of APC/C-Cdc20 mediated cyclin B degradation at elevated levels of Cdc2 activity prevents Cdc2 activity from reaching excessively high levels
O'Keefe et al., Proc Natl Acad Sci U S A 1991 : The c-mos gene product is required for cyclin B accumulation during meiosis of mouse eggs
Lorca et al., EMBO J 1991 : Degradation of the proto-oncogene product p39mos is not necessary for cyclin proteolysis and exit from meiotic metaphase : requirement for a Ca ( 2+ ) -calmodulin dependent event ... When free Ca2+ concentration is raised for only 30 s to the micromolar range, as occurs in physiological conditions after fertilization, cyclin degradation is induced , byt p39mos is not degraded