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Zeng et al., Zhongguo Yao Li Xue Bao 1999 : To study the intracellular signal transduction mechanisms of platelet activating factor (PAF) induced platelet P-selectin expression ... Human blood platelets were used to test the effect of PAF induced P-selectin expression using flow cytometry ... Pretreatment with egtazic acid ( EGTA ) 2 mmol.L-1 and 5,5'- dimethyl-bis- ( o-aminophenoxy ) -ethane-N, N,N ', N'-tetracetic acid ( BAPTA ) 200 mumol.L-1 to block Ca2+ influx or chelate the intracellular calcium, respectively, reduced P-selectin expression in response to PAF [ ( 13.3 +/- 0.9 ) % and ( 16.8 +/- 1.9 ) % vs ( 47.5 +/- 1.3 ) % of PAF group, P < 0.01 ]
Li et al., Thromb Res 2003 : In vitro stimulation with ADP, thrombin, or PAF increased platelet P-selectin expression and thus PLA formation, but these responses were not affected by aspirin
Guo et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005 : The results showed that the expression of CD62P on platelats, the expression of CD11b on neutrophils and PLA formation were all increased by PAF and ADP ; the PAF receptor antagonists ( GB ) could obviously inhibit the expression of CD62P , CD11b and PLA formation induced by PAF , but could not completely inhibit the activation of platelet and neutrophil, and the platelet-neutrophil cross talk ; GB could inhibit the expression of CD62P and CD11b induced by ADP, but could not conpletely inhibit the activation of platelet and neutrophli ; GB could not obviously inhibit the platelet-leucocyte aggregates mediated by ADP
Osborn et al., Am J Physiol Cell Physiol 2007 : However, physiologically relevant pGSN concentrations inhibit platelet activating factor (PAF) mediated P-selectin expression by up to 77 % ( P < 0.0001 )
Elstad et al., J Immunol 1995 : P-selectin did not directly stimulate synthesis of the lipid autoacoid platelet activating factor (PAF) ; however, incubation on immobilized P-selectin primed monocytes for increased synthesis of PAF in response to opsonized zymosan particles ... P-selectin increased PAF production by monocytes incubated with unopsonized zymosan particles that stimulate this response by interaction with the beta-glucan receptor
Ichikawa et al., Am J Physiol 1997 : Our results indicate that xanthine may promote neutrophil-endothelial adhesion via a hydrogen peroxide- and PAF mediated P-selectin expression