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IL13 — TYK2

Text-mined interactions from Literome

Subramaniam et al., Biochem Biophys Res Commun 1999 : Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells, interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3, Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Doucet et al., Oncogene 2000 (Lung Neoplasms...) : In addition to these pathways, in lung tumor myofibroblasts, IL-4 and IL-13 induced the phosphorylation of JAK3 and increased the phosphorylation of Tyk2
Doucet et al., Eur J Immunol 2002 (Inflammation) : Treatment with JAK3 inhibitors blocks IL-13 induced phosphorylation of JAK2, TYK2 and STAT3, but not of JAK1 and STAT6
Roy et al., J Leukoc Biol 2002 (Inflammation) : Earlier, our laboratory showed that IL-13 induced the phosphorylation of Jak2 and Tyk2 in monocytes and that expression of both Jaks was essential for downstream signaling by IL-13
Zhang et al., FASEB J 2012 (Hyperplasia...) : Mechanistically, Gab2 positively regulates IL-13 induced activation of TYK2/STAT6 by decreasing SOCS3 mediated degradation of TYK2
Bhattacharjee et al., Free Radic Biol Med 2013 : We further show that Jak2 is upstream of Stat3 activation and Tyk2 controls Stat1 and Stat6 activation in response to IL-13 stimulation
Welham et al., J Biol Chem 1995 (Leukemia, Erythroblastic, Acute...) : Both IL-13 and IL-4 induced low levels of tyrosine phosphorylation of Tyk-2 and Jak-1
Murata et al., Cell Immunol 1997 (Cell Transformation, Viral) : The phosphorylation level of Tyk2 was augmented at a low level in response to IL-13 and IL-4 in two of three cell lines ; however, IL-13 did not induce or augment phosphorylation of the other JAK kinases
Murata et al., Int Immunol 1998 : The Janus kinase (JAK)2 and Tyk2 were phosphorylated in response to IL-4 or IL-13 in sk559 and sk574 cell lines
Roy et al., J Biol Chem 1998 : Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes ... Our results suggest the novel finding that IL-13 can induce tyrosine phosphorylation of both Jak2 and Tyk2 in primary human monocytes