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CDKN1A — IRF1

Text-mined interactions from Literome

Wessely et al., Hum Mol Genet 2003 (Arteriosclerosis...) : IRF-1 leads to G ( 1 ) cell cycle arrest in CASMC and induces the CDK inhibitor p21
Passioura et al., Cancer Res 2005 (Disease Progression) : Antisense suppression of IRF-1 prevented N-rasG13R associated growth arrest and up-regulation of p21 ( CIP1/WAF1 )
Kokkinakis et al., Cancer Lett 2006 (Neoplasms) : The response of tumors to MET-stress depends on their mutational status, however, it always involves inhibition of CDK1 and in most cases the upregulation of p21 , p27, GADDs and 14-3-3sigma in response to upregulation of TGF-beta, IRF-1 , TNF-alpha, Rb and/or MDA-7 and the downregulation of PI3K, RAS and NF-kappaB