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RELA — USP11

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of 17 proteins Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of 16 proteins Bouwmeester et al., Nat Cell Biol 2004

Text-mined interactions from Literome

Yamaguchi et al., J Biol Chem 2007 : However, down-regulation of USP11 dramatically enhances NF-kappaB activity in response to tumor necrosis factor-alpha, indicating that IKKalpha does not require activation of NF-kappaB
Sun et al., Cell Signal 2010 : USP11 negatively regulates TNFalpha induced NF-kappaB activation by targeting on IkappaBalpha ... These data demonstrate that USP11 plays an important role in the downregulation of TNFalpha mediated NF-kappaB activation through modulating IkappaBalpha stability ... In addition, overexpression of a catalytically inactive USP11 mutant partially inhibits TNFalpha- and IKKbeta induced NF-kappaB activation, suggesting that USP11 also exerts a non-catalytic function in its negative regulation of TNFalpha mediated NF-kappaB activation