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RELA — TP63

Pathways - manually collected, often from reviews:

• FastForward regulation: RELA → TP63 (transcriptional regulation, increase) Wu et al., J Cell Biochem 2010*
  Evidence: REG, PROMACTIVITY, DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TP63 — RELA (physical association, affinity chromatography technology) Sen et al., J Biol Chem 2011*

Text-mined interactions from Literome

Du et al., Cell Immunol 2000 : SEB induced expression of the IL-12/p40 gene involves activation and nuclear translocation of nuclear factor kappaB (NF-kappaB)
Tomczak et al., J Immunol 2003 (Colitis) : NF-kappa B is required within the innate immune system to inhibit microflora induced colitis and expression of IL-12 p40
Dasgupta et al., Hybridoma (Larchmt) 2008 : On the other hand, antibodies produced from clones a3-3a and a3-7g specifically recognized p40 and inhibited p40- but not p40 ( 2 ) -, IL-12-, and IL-23 induced production of inflammatory molecules and activation of NF-kappaB
Ma et al., J Biol Chem 2009 (Acquired Immunodeficiency Syndrome) : HIV-1 Nef inhibits lipopolysaccharide induced IL-12p40 expression by inhibiting JNK activated NFkappaB in human monocytic cells
Rigaux et al., Allergy 2009 (Hypersensitivity) : IL-12 p40 secretion was dependent on nuclear factor-kappaB (NF-kappaB) , mitogen activated protein ( MAP ) kinases, Toll-like receptor 2 (TLR2), TLR9 and on the bacterial teichoic acid composition
Gri et al., J Biol Chem 1998 (Cell Transformation, Viral) : Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus transformed B cells and macrophages