Gene interactions and pathways from curated databases and text-mining

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RELA — TNFRSF10A

Text-mined interactions from Literome

Singh et al., Oncogene 2005 (Breast Neoplasms) : HDAC inhibitors synergized with TRAIL by inducing DRs DR4/TRAIL-R1 and DR5/TRAIL-R2 through NFkappaB activation and some of the proapoptotic members of the Bcl-2 family, and engaging the mitochondrial pathway
Shankar et al., Molecular cancer 2008 (Neoplasm Metastasis...) : In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4 , TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL