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RELA — TNFRSF10A
Text-mined interactions from Literome
Singh et al., Oncogene 2005
(Breast Neoplasms) :
HDAC inhibitors synergized with TRAIL by
inducing DRs
DR4/TRAIL-R1 and DR5/TRAIL-R2 through
NFkappaB activation and some of the proapoptotic members of the Bcl-2 family, and engaging the mitochondrial pathway
Shankar et al., Molecular cancer 2008
(Neoplasm Metastasis...) :
In xenogrfated tumors, curcumin upregulated the expression of
TRAIL-R1/DR4 , TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and
inhibited the activation of
NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL