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CCL20 — RELA
Pathways - manually collected, often from reviews:
-
WikiPathways EBV LMP1 signaling:
NFKB1/RELA
→
Complex of CXCL8-IFNB1-CCL20-TNF-CCL5
(activation)
Text-mined interactions from Literome
Sugita et al., J Immunol 2002
:
Induction of
macrophage-inflammatory protein-3alpha gene expression by TNF dependent
NF-kappaB activation ...
MIP-3alpha transcription was stimulated by TNF, and this stimulation was
inhibited by an
NF-kappaB inhibitor, I-kappaBalpha superrepressor ... These results clearly demonstrate that
MIP-3alpha gene expression is
dependent on
NF-kappaB activity in vitro, and indicate that the TNFR1 mediated TNF signaling cascade that leads to NF-kappaB activation plays an essential role in MIP-3alpha expression in the murine liver injury model
Hosokawa et al., Clin Exp Immunol 2005
:
On the other hand, we found that not only
NF-kappaB , p38 MAPK and ERK but also c-Jun NH2-terminal kinase (JNK) are
involved in
CCL20 production induced by E. coli LPS
Choi et al., World J Gastroenterol 2006
:
Although all three MAP kinase family members were phosphorylated in response to TNF-alpha, a selective inhibitor of p38 kinase SB203580 only could inhibit both
NF-kappaB dependent transcriptional activity and IL-8 and
CCL20 production, suggesting a potential link between p38 kinase and NF-kappaB dependent pathways in AGS cells
Gobert et al., J Immunol 2007
:
Consequently, the
NF-kappaB dependent
CCL20 and IL-8 gene transcription and chemokine production were enhanced in T84 cells infected with the Stx mutant in comparison to the wild-type strain
Tomimori et al., Infect Immun 2007
(Helicobacter Infections) :
Transfection of
IkappaB kinase and NF-kappaB inducing kinase dominant negative mutants inhibited H. pylori
mediated activation of
CCL20
Migita et al., Rheumatology (Oxford) 2009
(Arthritis, Rheumatoid) :
SAA induced
CCL20 production was
down-regulated by
NF-kappaB inhibition and partially by c-jun N-terminal kinase ( JNK ) inhibition
Dommisch et al., Innate Immun 2010
:
Phospholipase C, p38/MAPK, and
NF-kappaB mediated
induction of
MIP-3alpha/CCL20 by Porphyromonas gingivalis
Yamamoto et al., J Immunol 2012
(Pneumonia, Pneumococcal) :
Lung
CCL20 induction
required epithelial
RelA regardless of stimulus, whereas lung CXCL5 expression depended on RelA after instillation of LPS but not pneumococcus