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CDKN1A — RAF1

Text-mined interactions from Literome

Blagosklonny et al., Leukemia 1999 (Leukemia, Myeloid) : In comparison, the stimulation of Raf-1 by phorbol ester ( TPA ) activates the MAPK pathway, causes MAPK dependent p21WAF1/CIP1 induction, Rb dephosphorylation and growth arrest without Bcl-2 phosphorylation or apoptosis
Sun et al., Curr Biol 2000 : We have reported previously that p21 activated kinase 3 (Pak3) upregulates Raf-1 through direct phosphorylation on Ser338 [ 2 ]
Ramakrishna et al., Toxicol Appl Pharmacol 2002 (Lung Neoplasms) : These results suggest a possible tumor-suppressive function for K-ras p21 in lung and a positive role for raf-1 and Erk 1/2 in lung tumorigenesis
Yu et al., Blood 2003 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : These events were accompanied by down-regulation of the Raf-1/mitogen induced extracellular kinase ( MEK ) /extracellular signal related kinase ( ERK ) pathway as well as diminished expression of Bcr/Abl and cyclin D1, cleavage of p21CIP1 and phosphorylation of the retinoblastoma protein ( pRb ), and induction of the stress related kinases Jun kinase (JNK) and p38 mitogen activated protein kinase ( MAPK )
Williams et al., Proc Natl Acad Sci U S A 1992 : We show that either pp60v-src or p21c-ras can independently activate the autokinase activity of Raf-1 , but only to a limited extent ... Surprisingly, both pp60v-src and p21c-ras are required to fully activate Raf-1
Jin et al., J Biol Chem 2005 (MAP Kinase Signaling System) : p21 activated Kinase 1 (Pak1) dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association
Friedrich et al., J Hepatol 2005 (Carcinoma, Hepatocellular...) : Moreover, c-Raf-1 dependent induction of mdm2-P2 and p21cip1/waf1-promoter and elevated amounts of the respective proteins were observed in HBV producing cells
Ikeda et al., FEBS Lett 1995 : Phosphorylation of RGL did not affect its binding to ras p21 and rap1 p21 under the conditions that phosphorylation of Raf-1 reduced its affinity for ras p21
Blagosklonny et al., Cancer Res 1995 : These data suggest that induction of p21WAF1 by taxol requires c-raf-1 activity, but that it is not strictly dependent on wild-type p53
Kikuchi et al., J Biol Chem 1994 : To elucidate the role of post-translational modification of ras p21 in Raf-1 activation, we examined ras p21 dependent Raf-1 activity in baculovirus/Sf9 cells overexpressing Raf-1 and ras p21 ... However, neither the autophosphorylating activity of Raf-1 nor its ability to activate MEK was stimulated by v-ras p21 mutants which are not post-translationally modified ... These results indicate that the post-translational modification of ras p21 is necessary for Raf-1 activation but that the association of Raf-1 with ras p21 is not sufficient to activate Raf-1