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ATF4 — FGF2

Text-mined interactions from Literome

Malabanan et al., Circ Res 2008 (Carotid Artery Injuries...) : We demonstrate that ATF-4 is activated by fibroblast growth factor (FGF)-2 , an injury induced mitogen, through the phosphatidylinositol 3-kinase pathway ... FGF-2 induces ATF-4 binding to a recognition element located in the VEGF-A gene at +1767 bp and luciferase reporter gene expression dependent on this site ... These findings reveal, for the first time, the induction of ATF-4 by both vascular injury and FGF-2
Fei et al., Biochem Biophys Res Commun 2010 : Fibroblast growth factor 2 positively regulates expression of activating transcription factor 4 in osteoblasts ... We found that FGF2 stimulated ATF4 mRNA expression as early as 20 min and increased ATF4 protein expression after three hours of treatment ... This study is the first demonstration that ATF4 expression can be stimulated by FGF2 in osteoblasts and that ATF4 expression is significantly reduced in differentiated Fgf2 ( -/- ) BMSCs
Malabanan et al., J Mol Med (Berl) 2010 : ATF4 is induced in aortic smooth muscle cells by fibroblast growth factor 2 and in the intact vessel wall following balloon angioplasty