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BCL5 — EGFR
Text-mined interactions from Literome
Jost et al., J Biol Chem 2001
:
Epidermal growth factor receptor dependent control of keratinocyte survival and
Bcl-xL expression through a MEK dependent pathway
Bernal et al., Gastroenterology 2006
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Epidermal growth factor receptor signaling
regulates Bax and
Bcl-w expression and apoptotic responses during intestinal adaptation in mice
Zhao et al., J Lipid Res 2012
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Further studies showed that TNF-a decreased expression of the antiapoptotic proteins Bcl-2 and
Bcl-xL , decreased I?Ba and PPAR?, and also
inhibited PI3K dependent Akt and
EGFR signaling
Rodeck et al., Proc Natl Acad Sci U S A 1997
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Regulation of
Bcl-xL expression in human keratinocytes by cell-substratum adhesion and the
epidermal growth factor receptor
Stoll et al., Oncogene 1998
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Furthermore, stimulation of
EGFR signaling through two natural ligands, transforming growth factor (TGF)-alpha and epidermal growth factor (EGF),
increased the expression of
Bcl-XL in quiescent keratinocytes and HaCaT cells