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TRAF2 — TRAF3

Pathways - manually collected, often from reviews:

• BioCarta tnfr2 signaling pathway: TNF-beta/TNF R2/RIP/TRAF1/TRAF2/TRAF3/I-TRAF complex (TANK-TNFRSF1B-TRAF2-TRAF1-LTA-TRAF3-RIPK1) → MEKK1 (MAP3K1) (modification, activates)
• BioCarta tnfr2 signaling pathway: TNF-beta/TNF R2/RIP/TRAF1/TRAF2/TRAF3/I-TRAF complex (TANK-TNFRSF1B-TRAF2-TRAF1-LTA-TRAF3-RIPK1) → MAP3K14 (modification, activates)
• BioCarta tnfr2 signaling pathway: TNF R2/RIP/TRAF1/TRAF2/TRAF3/I-TRAF complex (TANK-TRAF3-TRAF2-RIPK1-TNFRSF1B-TRAF1) → TNF-beta (LTA) (modification, collaborate)
• BioCarta tnfr2 signaling pathway: TNF R2/RIP/TRAF1/TRAF2/TRAF3/I-TRAF complex (TANK-TRAF3-TRAF2-RIPK1-TNFRSF1B-TRAF1) → TNF-beta/TNF R2/RIP/TRAF1/TRAF2/TRAF3/I-TRAF complex (TANK-TNFRSF1B-TRAF2-TRAF1-LTA-TRAF3-RIPK1) (modification, collaborate)
  
• BioCarta tnfr2 signaling pathway: TNF-beta (LTA) → TNF-beta/TNF R2/RIP/TRAF1/TRAF2/TRAF3/I-TRAF complex (TANK-TNFRSF1B-TRAF2-TRAF1-LTA-TRAF3-RIPK1) (modification, collaborate)
  
• NCI Pathway Database CD40/CD40L signaling: cIAP1/cIAP2/TRAF2/TRAF3 complex (BIRC2-BIRC3-TRAF2-TRAF3) → NIK (MAP3K14) (modification, activates) Vallabhapurapu et al., Nat Immunol 2008, Zarnegar et al., Nat Immunol 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database CD40/CD40L signaling: TRAF3 (TRAF3) → cIAP1/cIAP2/TRAF2 complex (BIRC2-BIRC3-TRAF2) (modification, collaborate)
  Vallabhapurapu et al., Nat Immunol 2008, Zarnegar et al., Nat Immunol 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database CD40/CD40L signaling: TRAF3 (TRAF3) → cIAP1/cIAP2/TRAF2/TRAF3 complex (BIRC2-BIRC3-TRAF2-TRAF3) (modification, collaborate)
  Vallabhapurapu et al., Nat Immunol 2008, Zarnegar et al., Nat Immunol 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database CD40/CD40L signaling: cIAP1/cIAP2/TRAF2 complex (BIRC2-BIRC3-TRAF2) → cIAP1/cIAP2/TRAF2/TRAF3 complex (BIRC2-BIRC3-TRAF2-TRAF3) (modification, collaborate)
  Vallabhapurapu et al., Nat Immunol 2008, Zarnegar et al., Nat Immunol 2008
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TRAF2 — TRAF3 (direct interaction, fluorescent resonance energy transfer) He et al., J Biol Chem 2004*
• IRef Biogrid Interaction: TRAF2 — TRAF3 (physical association, affinity chromatography technology) He et al., J Biol Chem 2004*
• IRef Biogrid Interaction: TRAF2 — TRAF3 (physical association, affinity chromatography technology) Pullen et al., Biochemistry 1998
• IRef Biogrid Interaction: TRAF2 — TRAF3 (physical association, affinity chromatography technology) Li et al., Immunity 2011
• MIPS CORUM TANK-TRAF2-TRAF3 complex: TANK-TRAF2-TRAF3 complex complex (TANK-TRAF2-TRAF3) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of TANK-TRAF3-TRAF2-TANK-TRAF3-TRAF2 (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Zarnegar et al., Nat Immunol 2008
• IRef Hprd Interaction: TRAF3 — TRAF2 (in vivo) Mosialos et al., Cell 1995*
• IRef Hprd Interaction: Complex of 73 proteins (in vivo) Kuai et al., J Biol Chem 2003
• IRef Hprd Interaction: Complex of TRAF2-TANK-TRAF3-TRAF3-TANK-TRAF2-TANK-TRAF2-TRAF3 (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Intact Interaction: Complex of TRAF2-COG7-TRAF3-COG5 (association, anti tag coimmunoprecipitation) Li et al., Immunity 2011
• IRef Intact Interaction: Complex of BIRC2-TRAF2-TBK1-TRAF3-APBA3-TANK (association, anti tag coimmunoprecipitation) Li et al., Immunity 2011
• IRef Intact Interaction: Complex of 21 proteins (association, anti tag coimmunoprecipitation) Goncharov et al., EMBO J 2013
• IRef Intact Interaction: Complex of 19 proteins (association, anti tag coimmunoprecipitation) Goncharov et al., EMBO J 2013

Text-mined interactions from Literome

Conti et al., J Neurosurg 2005 (Brain Neoplasms...) : The authors investigated the expression of NF-kappaB, caspase 3, TRAF1, TRAF2 , and TRAF associated NF-kappaB activator/TRAF interacting protein ( TANK/I-TRAF ), a regulator of TRAF activity, in human gliomas
Graham et al., J Immunol 2009 : LMP1 does n't induce TRAF degradation, and employs TRAF3 as a positive mediator of cell signaling, whereas CD40 signals are inhibited by TRAF3
Valente et al., Free Radic Biol Med 2013 : AOPP-MSA stimulated Nox2/Rac1 dependent superoxide generation, TRAF3IP2 expression, and TRAF3IP2 dependent JNK activation