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LEP — TLR2

Text-mined interactions from Literome

Batra et al., Am J Pathol 2007 : With the present study we evaluated the Toll-like receptor ( TLR ) expression and TLR ligand-specific activation of murine preadipocytes and adipocytes in the presence [ wild type ( WT ), 3T3L1 ] or absence of leptin ( ob/ob ) or leptin signaling ( db/db )
Fortis et al., Salud Publica Mex 2012 (Obesity) : TLR activation is mediated by fatty acids and their expression is regulated by leptin , adiponectin and PPARs
Jaedicke et al., J Leukoc Biol 2013 : We therefore investigated a possible role for leptin in monocyte TLR and CD14 expression ... Leptin increased TLR2 cell-surface and mRNA expression in THP-1 and primary human monocytes ... In conclusion, we show that leptin and LPS differentially influence monocyte phenotype and demonstrate, for the first time, a regulatory effect of leptin on the monocyte expression of TLR2 ... Leptin stimulated TLR2 expression may potentiate innate immunity and inflammation in conditions of hyperleptinemia, such as obesity and T2DM
Cha et al., Endocrinology 2013 (Albuminuria...) : Recent evidence suggests that activation of Toll-like receptor ( TLR ) signaling induces peripheral insulin resistance and mediates central insulin and leptin resistance