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INS — PDC

Text-mined interactions from Literome

Stephens et al., Exp Physiol 2010 : This study investigated the effect of acute exercise on basal and insulin stimulated PDC activity ( the rate limiting step in glucose oxidation ), glycogen synthesis and the expression of metabolic genes and transcription factors associated with changes in PDC activation and glucose metabolism ... Collectively, these findings suggest that prior exercise does not alter basal and insulin stimulated PDC activation and the protein content of PDK4 the following day, but is associated with increased capacity ( through upregulation of hexokinase II content ) of muscle to phosphorylate and divert glucose towards glycogen storage
Buffington et al., Diabetes 1984 : Under optimal conditions of the assay, both BHI and porcine insulin activated PDC in a dose dependent fashion in which full activation of the enzyme was achieved with 10 ( -8 ) M insulin ... We conclude that the PDC of cultured human fibroblasts is activated by both human and porcine insulin at a comparable physiologic concentration