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CD28 — SLC22A3

Text-mined interactions from Literome

Teng et al., J Immunol 1996 (Leukemia) : Taken together, these results are consistent with a model in which activation of CD28 and LFA-1 induces tyrosine phosphorylation of the CD28 cytoplasmic domain, recruitment and activation of PI 3-kinase, as well as the Tec kinase Itk/Emt , and the activation of PMA-nonresponsive PKC isoenzymes
Gibson et al., J Biol Chem 1996 : Utilizing somatic cell mutants lacking LCK, we demonstrate that functional LCK is required for CD28 induced activation of EMT as evidenced by increased tyrosine phosphorylation and kinase activity ... In support of a role for LCK in EMT activation, reconstitution of a LCK negative Jurkat T cell line by transfection with normal LCK recreates CD28 mediated EMT activation
Gibson et al., Biochem J 1998 : Furthermore, PI3K is recruited to CD28 in JCaM1 cells which lack LCK and in which EMT/ITK is not activated by ligation of CD28
Lu et al., J Immunol 1998 : Ligation of the TCR or CD28 induces activation of phosphatidylinositol 3-kinase (PI3K), the TEC family protein tyrosine kinase, EMT/ITK/TSK ( EMT ) , and the SRC family tyrosine kinase, LCK ... We report herein that inhibition of PI3K activity with the specific inhibitors LY294002 and wortmannin markedly decreased EMT activation induced by CD28 cross linking but not by CD3 cross linking ... CD28 induced association of EMT with PI3K also requires functional expression of LCK