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RHOA — SEMA4D

Pathways - manually collected, often from reviews:

• Reactome Reaction: RHOA → SEMA4D (reaction) Hirotani et al., Biochem Biophys Res Commun 2002, Oinuma et al., J Biol Chem 2003, Swiercz et al., J Cell Biol 2004, Barberis et al., J Cell Sci 2005*

Text-mined interactions from Literome

Aurandt et al., Proc Natl Acad Sci U S A 2002 : Semaphorin 4D is the ligand for the plexin-B1 receptor and stimulation of the plexin-B1 receptor activates the small GTPase RhoA
Swiercz et al., J Cell Biol 2004 : A dominant negative form of ErbB-2 blocks Sema4D induced RhoA activation as well as axonal growth cone collapse in primary hippocampal neurons ... Our data indicate that ErbB-2 is an important component of the plexin-B receptor system and that ErbB-2 mediated phosphorylation of plexin-B1 is critically involved in Sema4D induced RhoA activation, which underlies cellular phenomena downstream of plexin-B1, including axonal growth cone collapse
Toguchi et al., Neurochem Int 2009 : We also provide evidence that LPS markedly upregulated Plexin-B1 expression in microglia and Sema4D/CD100 stimulated RhoA-activation in LPS activated microglia
Swiercz et al., Mol Cell Biol 2009 : The semaphorin 4D (Sema4D) receptor plexin-B1 constitutively interacts with particular Rho guanine nucleotide exchange factors ( RhoGEFs ) and thereby mediates Sema4D induced RhoA activation, a process which involves the tyrosine phosphorylation of plexin-B1 by ErbB-2
Negishi-Koga et al., Nat Med 2011 (Bone Resorption...) : The binding of Sema4D to its receptor Plexin-B1 on osteoblasts resulted in the activation of the small GTPase RhoA , which inhibits bone formation by suppressing insulin-like growth factor-1 (IGF-1) signaling and by modulating osteoblast motility