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BAG1 — BCL2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BCL2 — BAG1 (direct interaction, pull down) Takayama et al., EMBO J 1997*
• IRef Dip Interaction: BCL2 — BAG1 (physical association, two hybrid) Takayama et al., Cell 1995*
• IRef Hprd Interaction: BCL2 — BAG1 (in vitro) Takayama et al., EMBO J 1997*
• IRef Ophid Interaction: BCL2 — BAG1 (aggregation, confirmational text mining) Takayama et al., EMBO J 1997*
• IRef Ophid Interaction: BCL2 — BAG1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Sawitzki et al., Hum Gene Ther 2002 (Reperfusion Injury) : Bag-1 exerts powerful antiapoptotic effects by binding and stabilizing Bcl-2 and interacting with the tumor necrosis factor receptor type I-induced death signal
Yanada et al., Hum Gene Ther 2005 (Reperfusion Injury) : Thus, with dual gene cotransfer, coexistent Bcl-2 protein exerts no activity to assist a marked enhancement of BAG-1 protein, whereas the function of overexpressed BAG-1 as a Bcl-2 binding protein may lead to the enhancement of efficient expression of h-Bcl-2 in I/R treated liver as compared with nonischemic liver, which results in repression of diverse I/R induced cell death symptoms, presumably through the formation of functional complexes of BAG-1 and Bcl-2
Elstrand et al., Int J Gynecol Pathol 2009 (Carcinoma...) : Bag-1 , Bag-4, and HSP70 were detected in the tumor cell nuclei and cytoplasm, whereas HSP27, Bcl-2 , and Bcl-X ( L ) had exclusively cytoplasmic localization