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ATP5O — SPAST

Text-mined interactions from Literome

Evans et al., J Cell Biol 2005 (Spastic Paraplegia, Hereditary) : Using recombinant Spastin, we find that six mutant forms of Spastin , including three disease associated forms, are severely impaired in ATPase activity
Eckert et al., J Biol Chem 2012 : Several lines of evidence indicate that interactions among two subunits dominate the cooperative behavior : ( i ) the ATPase activity shows a sigmoidal dependence on the ATP concentration ; ( ii ) ATP?S displays a mixed-inhibition behavior for normal ATP turnover ; and ( iii ) inactive mutant subunits inhibit the activity of spastin in a hyperbolic dependence, characteristic for two interacting species