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IL12B — SOCS1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Davey et al., Tissue Antigens 2006
:
In addition, SOCS1 has a complex role in T cell activation, and studies have revealed significant
roles for
SOCS1 in the regulation of IL-4,
IL-12 and IL-15 in vivo
Jager et al., J Neuroimmunol 2011
(Encephalomyelitis, Autoimmune, Experimental) :
SOCS1-KIR also
blocked IL-23 and IL-17A activation of STAT3
Zhang et al., J Immunol 2011
(Hepatitis C, Chronic) :
Conversely, silencing
SOCS-1 expression using small interfering RNAs
increased IL-12 expression and inhibited PD-1 upregulation