◀ Back to SOS1

FGF2 — SOS1

Pathways - manually collected, often from reviews:

• Reactome Reaction: FGF2 → SOS1 (reaction) Hart et al., Oncogene 2000, Ong et al., Proc Natl Acad Sci U S A 2001, Hadari et al., Proc Natl Acad Sci U S A 2001, Weiss et al., Sci Transl Med 2010, Dutt et al., PloS one 2011, Wesche et al., Biochem J 2011, Klint et al., J Biol Chem 1995, Ong et al., Biochem Biophys Res Commun 1996, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Curto et al., Biochem Biophys Res Commun 1998, Raffioni et al., J Biol Chem 1998
• Reactome Reaction: FGF2 → SOS1 (indirect_complex) Hart et al., Oncogene 2000, Ong et al., Proc Natl Acad Sci U S A 2001, Hadari et al., Proc Natl Acad Sci U S A 2001, Weiss et al., Sci Transl Med 2010, Dutt et al., PloS one 2011, Wesche et al., Biochem J 2011, Klint et al., J Biol Chem 1995, Ong et al., Biochem Biophys Res Commun 1996, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Curto et al., Biochem Biophys Res Commun 1998, Raffioni et al., J Biol Chem 1998

Text-mined interactions from Literome

Fannon et al., J Cell Physiol 2008 (Carcinoma, Lewis Lung...) : Studies were then performed to assess the effect of SOS on basic fibroblast growth factor ( FGF-2 ) activity, a growth factor which promotes tumor and blood vessel growth and is produced by B16 melanoma cells ... SOS potently inhibited FGF-2 binding to endothelial cells and stripped pre bound FGF-2 from cells
Zhu et al., Structure 1993 : The SOS-FGF crystal structure is consistent with the model that SOS stabilizes FGF by neutralizing several positively charged residues that would destabilize the native structure by electrostatic repulsion
Arakawa et al., J Protein Chem 1993 : The effect of SOS on the thermal stability of bFGF was examined using denaturation at a constant heating rate, by both turbidity and differential scanning calorimetry
Kouhara et al., Cell 1997 : In this report, we describe the purification, cloning, and characterization of a novel protein, designated FRS2, that is tyrosine phosphorylated and binds to Grb2/Sos in response to FGF or NGF stimulation