UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to KRAS

GAB2 — KRAS

Pathways - manually collected, often from reviews:

NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → RAS family/GDP/Aiolos complex (HRAS_KRAS_HRAS_KRAS_NRAS-IKZF3) (modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database TCR signaling in naïve CD4+ T cells: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → GAB2 (GAB2) (modification, collaborate) Parry et al., J Immunol 2006, Egan et al., Nature 1993
Evidence: expresssion pattern, assay, other species
NCI Pathway Database TCR signaling in naïve CD4+ T cells: GAB2 (GAB2) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, inhibits)
Parry et al., J Immunol 2006, Egan et al., Nature 1993
Evidence: expresssion pattern, assay, other species
WikiPathways BDNF-TrkB Signaling: Complex of SHC1-GRB2-SOS1-GAB1-GAB2 → NRAS/KRAS/HRAS (activation)