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IKBKG — IL10
Text-mined interactions from Literome
Li et al., J Exp Med 1999
:
Accordingly, IKKbeta-deficient cells are defective in activation of
IKK and NF-kappaB in
response to either tumor necrosis factor alpha or
interleukin 1
Bhattacharyya et al., Blood 2004
:
Furthermore,
IL-10 blocked inducible Akt phosphorylation, and inhibitors of phosphatidylinositol 3-kinase (PI3K) effectively
suppressed the activation of Akt,
IKK , and NF-kappaB
Lamothe et al., J Biol Chem 2007
:
Reconstituting TRAF6-deficent cells with various TRAF6 mutants, we clearly demonstrate the requirement for the TRAF6 RING domain and site-specific auto-ubiquitination of TRAF6 to activate
IKK in
response to
interleukin-1
O'Connell et al., J Biol Chem 1998
:
Recently, we have reported that the tumor necrosis factor and
interleukin 1 signaling pathways
activate two kinases,
IKK1 and IKK2