Gene interactions and pathways from curated databases and text-mining

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MTX1 — TNFRSF11B

Text-mined interactions from Literome

Teramachi et al., Lab Invest 2011 (Arthritis, Experimental) : MTX suppressed the expression of mRNA for the receptor activator NF-?B ligand ( RANKL ), but it did not suppress the expression of osteoprotegerin (OPG)
Yao et al., Rheumatol Int 2013 : The effect of MTX and LEF on cell viability, and RANKL and OPG expression were indicated through MTT and RT-PCR analysis, respectively
Ding et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 2013 : To study the effects of Zhengqing Fengtongning Tablet ( ZFT ) and methotrexate (MTX) on the expression of osteoprotegerin (OPG) , receptor activator of nuclear factor-kappaB ligand ( RANKL ), and interleukin 17 (IL-17) in collagen induced arthritis ( CIA ) rats, thus addressing their bone protection