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FOS — HMOX1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lee et al., Am J Physiol Lung Cell Mol Physiol 2000
(Hyperoxia) :
Mutational analysis of the AB1 enhancer shows that
AP-1 is
essential for AB1 mediated
HO-1 gene transcription after hyperoxia
Rensing et al., Crit Care Med 2001
(Disease Models, Animal...) :
Thus,
AP-1 dependent
HO-1 induction under oxidative stress conditions may subserve a similar function as a stress-inducible vasodilator system as does NF-kappaB dependent iNOS expression in liver inflammation
Yang et al., Pediatr Res 2002
(Hyperoxia) :
These data suggest that the neonatal lung is relatively resistant to
AP-1 activation and
HO-1 induction by GSH perturbation
Kiemer et al., Endocrinology 2003
:
Cotreatment of the cells with U0126 or SP600125, as well as reporter gene assays revealed the
involvement of
AP-1/JNK activation in
HO-1 induction
Wu et al., J Card Fail 2004
(Anoxia) :
Furthermore, transfection assay using HO-1 promoter constructs revealed the
involvement of the nuclear factor kB (NF-kB) and
Activator protein-1 (AP-1) in the hypoxia induced activation of the
HO-1 gene
Miralem et al., J Biol Chem 2005
:
The following suggests BVR involvement in regulating oxidative stress response of HO-1 : siBVR attenuated As-mediated increase in
HO-1 expression ; siBVR, but not siHO-1, inhibited As-dependent increased c-jun promoter activity ; treatment of cells with As increased AP-1 binding of nuclear proteins ; BVR was identified in the DNA-protein complex ; and
AP-1 binding of the in vitro translated BVR was phosphorylation
dependent and was attenuated by biliverdin
Iles et al., Free Radic Biol Med 2005
:
Whereas inhibiting the ERK pathway with the MEK inhibitor PD98059 significantly decreased HNE mediated ERK phosphorylation,
c-Fos protein
induction , AP-1 binding, and
HO-1 protein induction, inhibition of the ERK pathway had no effect on HNE induced HO-1 mRNA ... Whereas inhibiting the ERK pathway with the MEK inhibitor PD98059 significantly decreased HNE mediated ERK phosphorylation, c-Fos protein induction,
AP-1 binding, and
HO-1 protein
induction , inhibition of the ERK pathway had no effect on HNE induced HO-1 mRNA
Fürst et al., J Pharmacol Exp Ther 2006
(MAP Kinase Signaling System) :
By applying activator protein-1 (AP-1) decoys, it was shown that the transcription factor
AP-1 is crucially
involved in the up-regulation of
HO-1 downstream of JNK
Harada et al., Free radical research 2008
:
Differential
roles for Nrf2 and
AP-1 in upregulation of
HO-1 expression by arsenite in murine embryonic fibroblasts
Baglole et al., Am J Physiol Lung Cell Mol Physiol 2008
(Inflammation...) :
Reduction of
c-Fos and c-Jun nuclear translocation by SP-600125
attenuated the CSE induced expression of
HO-1
Guan et al., J Cell Biochem 2008
(MAP Kinase Signaling System) :
Increased phospho p38 activity precedes and likely mediates HO-1 induction by EA. Increased
AP-1 binding may
underlie the transcriptional regulation of
HO-1 by EA
Park et al., Arch Pharm Res 2009
:
In contrast, SnPP treatment did not reverse YL-I-108 mediated suppression of AP-1 activation, suggesting that
AP-1 inhibition by YL-I-108 is
independent of
HO-1 induction
Yeligar et al., J Biol Chem 2010
:
Furthermore, livers of ethanol fed c-Jun ( fl/fl ) mice showed reduced levels of mRNA for HO-1 but not of NQO1 compared with ethanol fed control rats, supporting the
role of c-Jun or the
AP-1 transcriptional complex in ethanol induced
HO-1 expression
Camhi et al., Am J Respir Cell Mol Biol 1995
:
Induction of
heme oxygenase-1 gene expression by lipopolysaccharide is
mediated by
AP-1 activation ... Furthermore, upstream phosphorylation events modulate this
AP-1 dependent expression of the
HO-1 gene after LPS treatment
Camhi et al., Am J Respir Cell Mol Biol 1998
:
Mutational analysis of the AB1 enhancer and electrophoretic-mobility-shift assays of nuclear extracts from LPS treated cells further demonstrated that the transcription factor
activator protein-1 (AP-1) is
critical for AB1 mediated
HO-1 gene activation by LPS ... Taken together, these data suggest that LPS regulates HO-1 gene transcription in part by inducing the production of ROI, which initiate signal-transduction pathway ( s ) leading to the activation of
AP-1 dependent
HO-1 gene transcription