Foehr et al., J Neurosci 2000
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Although both p75 and TrkA activated nuclear factor-kappaB (NF-kappaB) , we show that distinct proximal signaling intermediates are used by each receptor ... A dominant negative mutant of TRAF6 blocked p75- but not TrkA mediated induction of NF-kappaB Kim et al., Toxicological sciences : an official journal of the Society of Toxicology 2009
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The MT-III induced antiapoptotic effects and increase in NF-kappaB activity were blocked by specific inhibitors of TrkA , phosphatidylinositol-3 kinase (PI3K), Akt, or NF-kappaB, indicating that MT-III provides neuronal protection by activating NF-kappaB through the TrkA/PI3K/Akt signaling pathway