Kim et al., J Biol Chem 2003
:
Leptin activated ERK, but not p38 and JNK, and up-regulated cPLA2 activity ; the latter was abolished by pre-treatment of cells with the MEK inhibitor ( PD98059 or U0126 ) or cPLA2 inhibitor ( AACOCF3 )
Slomiany et al., J Physiol Pharmacol 2007
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Furthermore, we show that leptin counters the pathological consequences of H. pylori induced cPLA(2) activation on gastric mucin synthesis through the involvement in signaling events controlled by MAPK/ERK and PI3K pathways
Deng et al., J Trauma Acute Care Surg 2012
(MAP Kinase Signaling System...) :
We further demonstrated that leptin markedly activated ERK1/2 in the intestines and activated ERK1/2 and cPLA2 in the cells
Liang et al., Int Immunopharmacol 2013
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Western blot and RT-PCR showed that leptin led to a reduction of cPLA2 activity and mRNA level, as well as caspase-3 cleavage