Singh et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Further, by using stable SH-SY5Y cell lines ( overexpressing wild-type, C277S mutant, and antisense TGase ), we demonstrate that transglutaminase activity is required for activation of RhoA , ERK1/2, JNK1, and p38gamma MAP kinases
Janiak et al., Mol Biol Cell 2006
:
Cell surface transglutaminase promotes RhoA activation via integrin clustering and suppression of the Src-p190RhoGAP signaling pathway