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CX3CR1 — TNF
Text-mined interactions from Literome
Croitoru-Lamoury et al., Glia 2003
:
Moreover,
TNFalpha and IL-1beta significantly
increase BOB/GPR15, CCR2, and
V28/CX3CR1 mRNA levels in both models
Chandrasekar et al., Biochem J 2003
:
TNF-alpha activated nuclear factor kappaB (NF-kappaB) and induced fractalkine and CX3CR1 expression in a time dependent manner in rat aortic SMCs. Transient transfections with dominant negative ( dn ) inhibitory kappaB (IkappaB)-alpha, dnIkappaB-beta, dnIkappaB kinase ( IKK)-gamma, kinase-dead ( kd ) NF-kappaB inducing kinase (NIK) and kdIKK-beta, or pretreatment with wortmannin, Akt inhibitor, pyrrolidinecarbodithioc acid ammonium salt ( ` PDTC ' ) or MG-132, significantly
attenuated TNF-alpha induced fractalkine and
CX3CR1 expression ... Taken together, our results demonstrate that
TNF-alpha induces the expression of fractalkine and
CX3CR1 in rat aortic SMCs and that this induction is mediated by NF-kappaB activation
Yano et al., Acta Med Okayama 2007
(Arthritis, Rheumatoid...) :
In the in vitro culture experiments, IL-10 induced
CX3CR1 expression on the surface of monocytes, and
TNFalpha induced membrane bound FKN as well as soluble FKN expression in synovial fibroblasts
Mizutani et al., J Immunol 2007
:
In contrast, pretreatment with 3 nM FKN induced higher levels of IL-23 compared with cells pretreated with 0.03 nM FKN and produced
TNF-alpha in a
CX3CR1 dependent manner
Sung et al., Cell Physiol Biochem 2010
:
Genistein also strongly suppressed
TNF-alpha induced expression of
CX3CR1 in monocytes
Xiong et al., J Immunol 2011
(Pulmonary Emphysema) :
Rather, functional
CX3CR1 was
required for a subset of tissue bound mononuclear phagocytes to produce
TNF-a and IL-6 in response to cigarette smoke, and the absence of functional CX3CR1 protected mice from developing tissue-destructive emphysema