Faibish et al., Mol Cancer Ther 2011
(Disease Progression...) :
mAY also abolished YKL-40 induced activation of the membrane receptor VEGF receptor 2 ( Flk-1/KDR ) and intracellular signaling mitogen activated protein ( MAP ) kinase extracellular signal regulated kinase ( Erk ) 1 and Erk 2
Areshkov et al., International journal of biological sciences 2012
(MAP Kinase Signaling System) :
In contrast to the activation of ERK1/2 phosphorylation by CHI3L1 that leads to a proliferative signal ( similar to the EGF effect in PC12 cells ), activation of ERK1/2 phosphorylation by CHI3L2 ( similar to NGF ) inhibits cell mitogenesis and proliferation