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KAT5 — SIRT1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: KAT5 — SIRT1 (physical association, affinity chromatography technology) Peng et al., Mol Cell Biol 2012*
• IRef Biogrid Interaction: KAT5 — SIRT1 (physical association, affinity chromatography technology) Wang et al., J Biol Chem 2010*
• IRef Biogrid Interaction: KAT5 — SIRT1 (physical association, affinity chromatography technology) Yamagata et al., Biochem Biophys Res Commun 2009*
• IRef Biogrid Interaction: KAT5 — SIRT1 (direct interaction, enzymatic study) Wang et al., J Biol Chem 2010*

Text-mined interactions from Literome

Yamagata et al., Biochem Biophys Res Commun 2009 : Moreover, Sirt1 deacetylates an acetylated Tip60 in response to DNA damage and stimulates proteasome dependent Tip60 degradation in vivo, suggesting that Sirt1 negatively regulates the protein level of Tip60 in vivo
Peng et al., Mol Cell Biol 2012 : Together, these findings uncover novel pathways in which SIRT1 dynamically interacts with and regulates hMOF and TIP60 through deacetylation and provide additional mechanistic insights by which SIRT1 regulates DNA damage response