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GYS1 — IGF1

Text-mined interactions from Literome

Youreva et al., Can J Physiol Pharmacol 2013 : In this study, we determined the effect of curcumin on IGF-1 induced phosphorylation of protein kinase B (PKB), glycogen synthase kinase-3ß ( GSK-3ß ) , and IGF-1R in VSMC
Yamamoto-Honda et al., J Biol Chem 1995 : Upstream mechanisms of glycogen synthase activation by insulin and insulin-like growth factor-I ... In contrast, wortmannin and 2- ( 4-morpholinyl ) -8-phenyl-4H-1-benzopyran-4-one ( LY294002 ), inhibitors of phosphatidylinositol 3-kinase, antagonized glycogen synthase activation in response to insulin or IGF-I
Cross et al., Biochem J 1994 : The results suggest that the stimulation of glycogen synthase by insulin/IGF-1 in skeletal muscle involves the MAP-KAP kinase-1 catalysed inhibition of GSK3, as well as the previously described activation of the glycogen associated form of protein phosphatase-1
Jaspers et al., J Mol Cell Cardiol 1993 (Diabetes Mellitus, Experimental...) : The ability of insulin, IGF-1 and IGF-2 to stimulate the activation of glycogen synthase in the heart was compared under completely defined conditions using primary culture cardiomyocytes ... These results suggest that ( 1 ) both insulin and IGF-1 are potent regulators of glycogen synthesis in the heart, ( 2 ) the enzymes involved in the dephosphorylation ( activation ) of glycogen synthase are closely linked to both insulin and IGF-1, but not IGF-2 receptor signaling pathways, ( 3 ) glycogen synthase activation is adversely affected by the maintenance of cardiomyocytes in the presence of palmitate or for > or = 24 h in hormone deficient media which results in insulin and IGF-1 resistance, and ( 4 ) this resistance, like that found in cells from diabetic rats, is due at least in part to a decrease in glycogen synthase phosphatase activity