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JAK3 — TYK2

Pathways - manually collected, often from reviews:

• BioCarta stat3 signaling pathway: Stat3 activating cytokines/cytokine receptor/JAKs/TYK2 complex (JAK2_JAK1_JAK3-TYK2) → STAT3 (modification, activates)
• BioCarta stat3 signaling pathway: Stat3 activating cytokines/cytokine receptor/JAKs/TYK2 complex (JAK2_JAK1_JAK3-TYK2) → Cytokine receptor/JAKs/TYK2 complex (TYK2-JAK2_JAK1_JAK3) (modification, collaborate)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TYK2 — JAK3 (physical association, affinity chromatography technology) Doucet et al., Eur J Immunol 2002*
• IRef Innatedb Interaction: TYK2 — JAK3 (unknown, -) Doucet et al., Eur J Immunol 2002*

Text-mined interactions from Literome

Shang et al., Cancer Sci 2007 (Carcinoma, Renal Cell...) : The results suggest that the resistance of RCC to IFN-alpha is associated with the lack of Jak1, Tyk2 and Stat1 expression and defective Jak-Stat activation , but not with a lack of IFN-alpha receptor, suppressors of cytokine signaling induction or other factors examined
Dedoni et al., J Neurochem 2010 (Neuroblastoma) : Janus kinase inhibition reduced IFN-ß stimulated TyK2 and STAT1 phosphorylation, STAT1 transcriptional activity, induction of double stranded RNA activated protein kinase ( PKR ) and caspase cleavage