Pinton et al., Cancer Res 2009
(Disease Progression...) :
Moreover, studies in vitro confirmed that treatment with 17beta-estradiol led to an ERbeta mediated inhibition of malignant mesothelioma cell proliferation as well as p21 ( CIP1 ) and p27 ( KIP1 ) up-regulation
Jeon et al., Cell Signal 2012
:
To investigate the role of p27 on estrogen receptor ( ER ) a-mediated transcription, we generated MCF-7 cells with knocked down p27 via retroviral delivery of p27 shRNA