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CXCL10 — JUN
Text-mined interactions from Literome
Cinatl et al., Int J Mol Med 2005
(Colonic Neoplasms...) :
High hydrocortisone concentrations ( > or =50 microg/ml ) completely prevented increased DNA binding activity of
AP-1 and NF-kappaB and
inhibited up-regulation of
CXCL8 and CXCL10, but did not reduce chemokine expression to basal levels ... High hydrocortisone concentrations ( > or =50 microg/ml ) completely prevented increased DNA binding activity of
AP-1 and NF-kappaB and
inhibited up-regulation of CXCL8 and
CXCL10 , but did not reduce chemokine expression to basal levels
D'Aversa et al., J Neurosci Res 2008
(AIDS Dementia Complex...) :
Gel shift analyses demonstrated that NFkappaB and
AP-1 , but not C/EBPbeta,
mediate microglial
CXCL8 production
Li et al., J Clin Endocrinol Metab 2011
(Inflammation...) :
In IL-1ß- or TNF-a stimulated first trimester decidual cells, NF?B inhibitor suppressed production of all six chemokines ;
JUN NH2-terminal kinase inhibitor
inhibited secretion of CCL2, CCL4, and CCL5 ; and MAPK kinase and p38 inhibitor decreased production of
CXCL8
Tsai et al., J Investig Med 2011
(Inflammation...) :
Only extracellular signal regulated kinases and
c-Jun N-terminal kinases (JNK) mitogen activated protein kinase inhibitors
suppressed LPS induced
IP-10 expression ... Its suppressive effect on TNF-a, I-309, and
IP-10 may, at least in part,
involve the down-regulation of LPS induced
MKK4-JNK-c-Jun expression