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FOS — SRF
Pathways - manually collected, often from reviews:
-
FastForward regulation:
SRF
→
FOS
(transcriptional regulation, unknown)
Cooper et al., Genome Res 2007
Evidence: DNABINDING
-
FastForward regulation:
SRF
→
FOS
(transcriptional regulation, unknown)
Chaudhary et al., Mol Endocrinol 1999*, Bernal-Mizrachi et al., J Biol Chem 2000*, White et al., Biochemistry 2000*, Drewett et al., J Biol Chem 2001*
Evidence: DNABINDING
-
FastForward regulation:
SRF
→
FOS
(transcriptional regulation, unknown)
Boulden et al., Mol Cell Biol 1992*, Metz et al., Genes Dev 1991*, de Belle et al., Mol Cell Biol 1991*, Latinkic et al., Nucleic Acids Res 1991*, Rivera et al., Genes Dev 1990*
Evidence: DNABINDING
-
FastForward regulation:
SRF
→
FOS
(transcriptional regulation, unknown)
Gille et al., Nature 1992*, Dalton et al., Cell 1992*, Treisman et al., EMBO J 1992*, Gualberto et al., Mol Cell Biol 1992*, Shaw et al., EMBO J 1992*
Evidence: DNABINDING
-
KEGG MAPK signaling pathway:
Complex of ELK1-ELK4-SRF
→
FOS
(gene expression, expression)
Text-mined interactions from Literome
Bruning et al., Proc Natl Acad Sci U S A 2000
:
Thus Rsk-2 is required for growth factor stimulated expression of
c-Fos and transcriptional
activation of Elk-1 and the
serum response factor , but not for activation of CREB or the mitogen activated protein kinase pathway in response to PDGF and IGF-1 stimulation
Hao et al., FEBS Lett 2006
:
Mutants of ITK that lack kinase activity or a kinase domain can rescue cells lacking Tec family kinases for antigen receptor induced
SRF activation, but not for NFAT,
AP-1 or NFkappaB
activation
Nagashima et al., J Biol Chem 2011
(Ataxia) :
Mutation analysis indicated that the nuclear localization signal and both the N- and C-terminal regions of CRAG are critical for
SRF dependent
c-Fos activation