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FOS — PIK3R1
Text-mined interactions from Literome
Baumgartner et al., Cell Microbiol 2000
:
PI3-K induction of GM-CSF appears to be at the transcriptional level and, consistently, we demonstrate that
PI3-K is also
involved in the constitutive induction of
AP-1 and NF-kappaB, which characterizes Theileria infected leucocytes
Bian et al., Invest Ophthalmol Vis Sci 2004
:
PI3K dependent induction of hRPE c-fos and
AP-1 nuclear translocation may be a target for therapies aimed at modulating MCP-1 in retinal diseases
Park et al., Toxicol Appl Pharmacol 2006
(Lymphoma) :
In contrast, the enhanced
AP-1 DNA binding activities and p38 MAPK phosphorylation were significantly
suppressed by specific inhibitors for PKC and p38 MAPK, but not by
PI3-K inhibitors
Song et al., Gut 2007
(Adenocarcinoma...) :
Unconjugated bile acids
induce CREB and
AP-1 dependent COX-2 expression in Barrett 's oesophagus and OA through ROS mediated activation of
PI3K/AKT and ERK1/2
Han et al., Toxicol Appl Pharmacol 2008
:
Phosphatidylinositol 3 (PI3)-kinase , its downstream signaling molecule, Akt, and mitogen activated protein kinases ( MAPK ) were also significantly
activated by the o, p'-DDT induced
AP-1 and CRE activation
Kajanne et al., Int J Oncol 2009
(Prostatic Neoplasms) :
Here, we show that constitutive
AP-1 activity in prostate cancer cells is
dependent on the activities of EGF-R and
PI3K ... Together, the findings show that
AP-1 activity in prostate cancer cells
mediates EGF-R and
PI3K signalling, is essential for their proliferation, and confers protection against radiation induced cell death
Kim et al., FEBS Lett 2012
(Atherosclerosis) :
ROS mediated c-Jun NH ( 2 ) -terminal kinase ( JNK ) is also required for AP-1 activation, but Syk and
PI3K regulated
AP-1 activation independently of JNK