◀ Back to IL10
CREB5 — IL10
Text-mined interactions from Literome
Leceta et al., Ann N Y Acad Sci 2000
(Inflammation) :
VIP/PACAP inhibit iNOS expression through reduction in NFkB and IRF-1 binding, and
augment IL-10 by increasing
CREB binding
Park et al., J Leukoc Biol 2008
:
Further, overexpression of a dominant negative form of
CREB suppressed gAcrp induced transcriptional activation of
IL-10
Pongratz et al., Ann Rheum Dis 2012
(Arthritis, Experimental) :
Interleukin 10 (IL-10) producing B cells suppress arthritis and are a potential target of the SNS because ( 1 ) B cells express functional ß ( 2 ) -adrenoceptors ( ß ( 2 ) ARs ) and ( 2 )
IL-10 , at least in monocytes/macrophages, is regulated in a
cAMP/PKA/CREB dependent manner
Koscsó et al., J Immunol 2012
(MAP Kinase Signaling System) :
Silencing CREB using lentivirally delivered short hairpin RNA blocked the enhancing effect of adenosine on IL-10 production, confirming a
role for
CREB in mediating the stimulatory effect of adenosine on
IL-10 production
Nandan et al., J Immunol 2012
(Leishmaniasis, Visceral) :
Infection of macrophages with leishmania induced phosphorylation of CREB at serine 133, and this was associated with enhanced
CREB DNA binding activity and
induction of
IL-10
Ji et al., Liver Transpl 2012
(Disease Models, Animal...) :
Liver protection due to cAMP-PKA stimulation was accompanied by diminished neutrophil and macrophage infiltration/activation, reduced hepatocyte necrosis/apoptosis, and increased cAMP response element binding protein (
CREB ) expression and
augmented interleukin-10 (IL-10) expression
MacKenzie et al., J Immunol 2013
:
However, although
CREB regulates
IL-10 transcription, the mutation of Ser ( 133 ) to Ala in the endogenous CREB gene did not prevent the ability of PGE ( 2 ) to promote IL-10 transcription
Elcombe et al., PloS one 2013
:
Furthermore, we show that MSKs regulate dectin-1 induced
IL-10 production, and that this regulation is
dependent on the ability of MSKs to phosphorylate the transcription factor
CREB
Wang et al., J Biol Chem 1995
:
Several other transcription factors including NF-IL-6, AP-1, AP-2, GR,
CREB , Oct-1, and Sp-1 are not
affected by
IL-10