Gene interactions and pathways from curated databases and text-mining

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ICOSLG — IL21

Text-mined interactions from Literome

Wahl et al., J Am Soc Nephrol 2002 : Interestingly, interleukin-2 production by T cell hybridomas after antigen presentation by TEC was enhanced by blocking antibodies to B7RP-1 and ICOS
de Haij et al., Kidney Int 2005 : Stimulation with interferon-gamma (IFN-gamma) resulted in increased expression of B7-H1, whereas ICOS-L expression was marginally increased upon stimulation with CD40L, with no effect of interleukin ( IL-1 ), IL-17, or tumor necrosis factor-alpha (TNF-alpha)
Nurieva et al., Immunity 2008 : Tfh cell generation was regulated by ICOS ligand (ICOSL) expressed on B cells and was dependent on interleukin-21 (IL-21) , IL-6, and signal transducer and activator of transcription 3 ( STAT3 )
Penel-Sotirakis et al., PloS one 2012 : IL-21 and IL-22 production were dependent on the B7/CD28 co-stimulatory pathway and ICOS-L expression on skin LCs significantly reduced IL-21 level