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IRF6 — PPARA

Text-mined interactions from Literome

Barclay et al., J Pharmacol Exp Ther 1999 (Endotoxemia) : Because induction of the CYP4A subfamily by chemicals requires peroxisome proliferator activated receptor-alpha ( PPARalpha ), we determined whether CYP4A induction by LPS also requires PPARalpha by comparing the responses of PPARalpha-null ( -/- ) and wild-type ( +/+ ) mice
Feingold et al., J Lipid Res 2008 : LPS also caused a reduction in renal mRNA levels of PPARalpha ( 75 % decrease ), thyroid hormone receptor alpha (TRalpha) ( 92 % decrease ), and TRbeta ( 84 % decrease ), whereas PPARbeta/delta and gamma were not altered
Maitra et al., Mol Immunol 2009 (Endotoxemia) : We observed that LPS selectively suppresses the levels of PPARalpha and PGC-1alpha in tissues from WT, but not IRAK-1 ( -/- ) mice
Selvaraj et al., Comp Biochem Physiol A Mol Integr Physiol 2010 (Inflammation) : The LPS induced PPARalpha and RXRalpha downregulation were partially reversed by increasing the dietary lutein content to 50mg/kg feed in experiment I and by increasing the dietary PUFA fat content to 6 % in experiment II
Yi et al., Zhonghua Yan Ke Za Zhi 2011 (Graves Disease...) : LPS can induce inflammatory response of orbital preadipocytes in TAO and enhance the expression of COX2, PPAR? and PGE ( 2 )
Du et al., Br J Pharmacol 2011 (Inflammation...) : Moreover, exogenous application of 2-AG or elevation of endogenous 2-AG by inhibiting its hydrolysis with URB602 or JZL184, selective inhibitors of monoacylglycerol lipase (MAGL), prevented the IL-1ß- and LPS induced reduction of PPAR? expression
Finlin et al., Metab Syndr Relat Disord 2012 : Small interfering RNA ( siRNA ) -mediated knockdown of SUMO-1 decreased PPAR? , HDAC3, and NCoR in THP-1 cells and increased tumor necrosis factor-a (TNF-a) induction in response to lipopolysaccharide (LPS)
Chai et al., PloS one 2013 (Plaque, Atherosclerotic) : In THP-1 cells NA suppressed LPS induced mRNA transcription of MCP-1 by 76.6±12.2 % ( P < 0.01 ) and TNFa by 56.1±11.5 % ( P < 0.01 ), yet restored LPS induced suppression of PPAR? transcription by 536.5±46.4 % ( P < 0.001 ) and its downstream effector CD36 by 116.8±19.8 % ( P < 0.01 )