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IRF6 — PLA2G4A

Text-mined interactions from Literome

Lupo et al., Biochim Biophys Acta 2001 : LPS ( 1 microg/ml ), t-BuOOH ( 200 microM ), and oxLDL ( 100 microM ), but not native LDL, incubated for 24 h with cells, markedly increased lipid peroxidation, cytosolic phospholipase A2 (cPLA2) activity and arachidonic acid ( AA ) release in a time- and dose dependent manner
Barnett et al., J Surg Res 2001 : Pretreatment with BAPTA A.M. attenuated HUVEC cPLA(2) activity in response to LPS
Grossman et al., Int J Surg Investig 2000 : Murine epithelial cells increased PGE2 formation in response to IL-1 and Ca Ion, but not LPS and the increased PGE2 was significantly decreased by cPLA2 enzyme inhibitors
Dieter et al., Cell Signal 2002 : In addition, LPS induces an enhanced expression of cPLA2 mRNA ( after 2-4 h ) and an enhanced expression of cPLA2 protein ( after 8 h )
Jiang et al., Mol Cell Biochem 2003 : In this study, the effect of phorbol 12-myristate 13-acetate ( PMA ), tumor necrosis factor alpha (TNFalpha), lipopolysaccharide (LPS) and macrophage-colony stimulating factor ( M-CSF ) on AA release and prostaglandin E2 ( PGE2 ) production and the expression of cPLA2 and COX-1 and -2 were investigated in U937 human pre-monocytic cells and fully differentiated macrophages
Park et al., Biochemistry 2005 : Inhibition of NF-kappaB by cobrotoxin resulted in reductions in the LPS induced expressions of COX-2, iNOS, cPLA(2) , IL-4, and TNF-alpha in astrocytes and in COX-2 expression induced by SNP, LPS, and TNF-alpha in astrocytes
Qi et al., J Biol Chem 2005 (MAP Kinase Signaling System) : Here, we found that Toll-like receptor 4 (TLR4) is essential for LPS induced cPLA(2) activation and lipid release ... Furthermore, activation of the TLR4 signaling pathway by LPS regulated cPLA(2) activation and lipid release
Luo et al., Cell Signal 2006 (MAP Kinase Signaling System) : However, the intracellular signaling pathways mediating LPS induced cPLA2 expression and PGE2 synthesis in canine tracheal smooth muscle cells ( TSMCs ) remains unknown ... LPS induced expression of cPLA2 and release of PGE2 was attenuated by inhibitors of tyrosine kinase ( genistein ), phosphatidylcholine-phospholipase C ( D609 ), phosphatidylinositol-phospholipase C ( U73122 ), PKC ( GF109203X and staurosporine ), removal of Ca2+ by BAPTA/AM plus EDTA, MEK1/2 ( PD98059 ), p38 ( SB202190 ), JNK ( SP600125 ), and phosphatidylinositol 3-kinase ( PI3-K ; LY294002 and wortmannin ) ... LPS induced cPLA2 expression and PGE2 synthesis was inhibited by a selective NF-kappaB inhibitor ( helenalin ) and transfection with dominant negative mutants of NF-kappaB inducing kinase (NIK), IkappaB kinase (IKK)-alpha, and IKK-beta, consistent with that LPS stimulated both IkappaB-alpha degradation and NF-kappaB translocation into nucleus in these cells ... LPS stimulated cPLA2 phosphorylation was inhibited by PD98059, GF109203X, and staurosporine, indicating the regulation by p42/p44 MAPK and PKC ... Moreover, LPS induced up-regulation of cPLA2 and COX-2 linked to PGE2 synthesis was inhibited by AACOCF3 ( a selective cPLA2 inhibitor ), implying the involvement of cPLA2 in these responses
Kim et al., Shock 2006 (Death...) : Similarly, the LPS stimulated cPLA2 activity was also inhibited by Gln treatment after LPS injection ... Moreover, a cPLA2 inhibitor not only inhibited LPS induced activation of cPLA2 , but also significantly prevented LPS mediated death
Slomiany et al., IUBMB Life 2006 : The blockade of ERK caused also inhibition of the LPS induced cPLA2 activation and amplification in the impedance capacity of PAF antagonist on the LPS induced ET-1 generation, while the inhibitor of PI3K had no effect
Lee et al., Neurosci Res 2006 : SG ( 10-100 microg/ml ) inhibited LPS induced generation of nitric oxide ( NO ) and reactive oxygen species ( ROS ), as well as inhibited LPS induced cytosolic phospholipase A2 (cPLA2) , cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression dose-dependently
Slomiany et al., Inflammopharmacology 2006 : The blockade of ERK caused also inhibition of the LPS induced cPLA2 activation and amplification in the impedance capacity of PAF antagonist on the LPS induced ET-1 generation, while the inhibitor of PI3K had no effect
Slomiany et al., J Physiol Pharmacol 2007 : In this study, we report on the role of leptin in modulation of the detrimental consequences of H. pylori LPS induced cPLA(2) activation that result in the disturbances in gastric mucin synthesis ... Employing gastric mucosal cells labeled with [ ( 3 ) H ] arachidonic acid, we show that H. pylori LPS induced cPLA(2) activation, associated with up-regulation in apoptosis and PAF generation, and the impairment in gastric mucin synthesis, was subject to a dose dependent suppression by leptin, as well as the inhibition by MAFP, a specific inhibitor of cPLA(2) ... The results of our findings point to H. pylori LPS induced ERK dependent cPLA(2) activation as a critical factor influencing the level of PAF generation, and hence the extent of pathological consequences of H. pylori infection on the synthesis of gastric mucin
Lv et al., Inflamm Res 2010 (Inflammation) : The aim of this study was to study the effect of caveolin-1 on the cytosolic phospholipase A2 (cPLA2) , p38 mitogen activated protein kinase ( p38 MAPK ) and nuclear factor kappaB (NF-kappaB) in mouse lung alveolar type-1 cells' (AT-1 cells) inflammatory response induced by LPS
Wu et al., J Cell Physiol 2010 (Arthritis, Rheumatoid) : Subsequently, the LPS stimulated cPLA(2)alpha phosphorylation was attenuated by pretreatment with a MEK1/2 inhibitor ( U0126 ), suggesting that LPS stimulated cPLA(2)alpha phosphorylation and activity are mediated through an ERK dependent mechanism
Lin et al., Br J Pharmacol 2011 : However, the exact mechanisms by which HuR affects the stability of mRNA and modulates LPS induced COX-2 and cPLA(2) expression in human tracheal smooth muscle cells ( HTSMCs ) are not known ... CONCLUSIONS AND IMPLICATIONS These results suggested that in HTSMCs, LPS induced COX-2 and cPLA(2) expression is mediated through NADPH oxidase/ROS dependent MAPKs associated with HuR accumulation in the cytoplasm
Vana et al., Exp Neurol 2011 (Disease Models, Animal...) : In primary cultures of microglia, lipopolysaccharide (LPS) induced an upregulation of cPLA(2) , inducible nitric oxide synthase (iNOS) and components of the NADPH oxidase complex, p47phox and p67phox
Shoeb et al., Free Radic Biol Med 2011 (Inflammation) : LPS induced activation of cPLA2 was also prevented by AR inhibition
Shoeb et al., Free Radic Biol Med 2012 (Inflammation) : Benfotiamine prevented the LPS induced activation of cPLA2 and release of AA metabolites such as leukotrienes, prostaglandin E2, thromboxane 2 ( TXB2 ), and prostacyclin ( PGI2 ) in macrophages
Slomiany et al., Inflammopharmacology 2013 : We show that ERK activation by the LPS leads to phosphorylation of the inhibitory ?B kinase-ß ( IKK-ß ) and cytosolic phospholipase A2 (cPLA2) , and is reflected in the upsurge in NF-?B nuclear translocation, induction in COX-2 and iNOS expression, and up-regulation in cPLA2 activity
Soliman et al., Lipids 2013 : In primary astrocytes, LPS increased the phosphorylation of cPLA2 and increased the levels of Cox-1 and Cox-2
Syrbu et al., J Immunol 1999 : LPS increases cPLA2 phosphorylation and arachidonic acid release