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IRF6 — LTB

Text-mined interactions from Literome

Zinetti et al., Cytokine 1998 (Sepsis) : Neither the pro-inflammatory cytokines interleukin 2 (IL-2), TNF-alpha nor LPS alone or in combination with interferon gamma (IFN-gamma) had any effect on LT-beta mRNA expression
Brideau et al., Br J Pharmacol 1999 : 4. LPS-stimulation of whole blood for either 30 min or 24 h followed by N-formyl-Met-Leu-Phe ( fMLP ) activation resulted in low plasma LTB4 levels
Park et al., J Neurochem 2003 (Inflammation) : We observed that ( i ) chloroquine augmented LPS induced expression of pro-inflammatory cytokines such as lymphotoxin (LT)-beta , tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta and IL-6 in human astroglial cells, while the same treatment suppressed LPS induced expression of cytokines in monocytic and microglial cells ; ( ii ) chloroquine alone induced expression of pro-inflammatory cytokines in a dose- and time dependent manner in astroglial cells ; ( iii ) other lysosomotropic agents such as ammonium chloride and bafilomycin A1 had minimal effects on cytokine expression ; and ( iv ) chloroquine induced the activation of nuclear factor-kappa B in astroglial cells, which is a required component of chloroquine induction of cytokines
Buduneli et al., J Periodontol 2004 (Alveolar Bone Loss...) : Doxycycline + alendronate + LPS group also significantly reduced LTB4 and PAF levels, although doxycycline provided the most reduction in the levels of these mediators ( P < 0.05 )
Marcouiller et al., J Rheumatol 2005 (Osteoarthritis, Knee) : Under lipopolysaccharide (LPS) stimulation, both licofelone ( COX/LOX inhibitor ) at therapeutic concentrations and NDGA ( LOX inhibitor ) inhibited LTB4 production, whereas naproxen did not amplify the LPS induced LTB4 production
Kono et al., Mol Immunol 2006 : In head kidney cells, expression of LT-beta1 and TNF-alpha ( 1, 2 ) genes was increased by stimulation with PHA or LPS
Elvevoll et al., Lipids 2006 : EPA and DHA were negatively correlated with LPS induced TNFalpha, IL-8, LTB4 , TxB2, and TF in whole blood
Deslee et al., Respir Res 2007 (Pneumonia...) : Interestingly, LPS induced a higher release of IL-8, but not PGE2 and LTB4 in COPD BES ( p < 0.001 ) which correlated with lung function changes
Mao et al., Cancer prevention research (Philadelphia, Pa.) 2008 (Carcinoma...) : LPS induced the release of LTB4 from BAL cells and down-regulated 5-lipoxygenase (5-LOX) mRNA expression in a dose dependent manner, followed by a decrease in 5-LOX protein production and normalization of LTB4 levels ... LPS concomitantly induced expression and activity of the LTB4 metabolizing enzyme LTB4 omega-hydroxylase (LTB4OH) in ex-smokers ' BAL cells, but not in smokers ' BAL cells ... In vitro smoke exposure of ex-smokers ' BAL cells also abrogated the LPS induced up-regulation of LTB4OH mRNA expression
Ovrevik et al., Toxicology 2009 (Lung Neoplasms) : After 10h exposure, silica induced significantly increased expression of CCL20, CXCL1/-3/-8/-10/-11, lymphotoxin (LT)beta and interleukin (IL)-6 ; ufCB induced CXCL8/-10 and -11 ; ZnCl ( 2 ) induced CCL11/-20/-26, CXCL1/-5/-8/-14 and tumor necrosis factor (TNF)-alpha ; FeSO ( 4 ) induced a weak up-regulation of CXCL8 and TNF-alpha ; LPS induced CCL20, CXCL1/-5/-8/-10/-11, LTbeta and IL-6 ; and 1-NP induced expression of CCL20, CXCL1/-3/-8, TNF-alpha and IL-6
Bhavsar et al., Respir Res 2010 (Asthma) : LPS induced LTB4 was increased in severe asthma compared to non-severe asthma ( p < 0.05 ) ... Dexamethasone inhibited LPS induced LTB4 and LXA4, with lesser suppression of LTB4 in severe asthma patients ( p < 0.05 ) ... Decreased LXA4 and increased LTB4 generation plus impaired corticosteroid sensitivity of LPS induced LTB4 but not of LXA4 support a role for AMs in establishing a pro-inflammatory balance in severe asthma
Rankin et al., J Clin Invest 1990 : The capacity of lipopolysaccharide (LPS) , zymosan, and calcium ionophore A23187 to induce neutrophil chemotactic activity (NCA), leukotriene B4 (LTB4) , and neutrophil attractant/activation protein ( NAP-1 ) release from human alveolar macrophages ( AM ) retrieved from normal nonsmokers was evaluated ... LPS induced a dose dependent release of LTB4 that began by 1 h, 4.0 +/- 3.2 ng/10 ( 6 ) viable AM ; peaked at 3 h, 24.7 +/- 13.5 ng/10 ( 6 ) viable AM ; and decreased by 24 h, 1.2 +/- 1.0 ng/10 ( 6 ) viable AM ( n = 8 ) ... By contrast, NAP-1 release began approximately 3-5 h after stimulation of AM with LPS, 197 +/- 192 ng/ml, and peaked at 24 h, 790 +/- 124 ng/ml. Release of NAP-1 was stimulus specific because A23187 evoked the release of LTB4 but not NAP-1, whereas LPS and zymosan induced the release of both LTB4 and NAP-1
Sahin et al., Arch Ophthalmol 2012 : To test the hypotheses that lipopolysaccharide (LPS) stimulates leukotriene B4 (LTB4) production in human ocular surface and adenexal cells, arachidonic acid duplicates the stimulatory effect of LPS, LPS binding protein potentiates LPS induced LTB4 secretion, and dihydrotestosterone attenuates the immune effect of LPS
Doerfler et al., J Clin Invest 1989 : We investigated the in vitro effects of LPS on neutrophil production of LTB4 and the omega-oxidation metabolites of LTB4 ... LPS did not result in LTB4 production in response to the chemoattractant peptide FMLP
Goldman et al., J Immunol 1986 : Decreased receptor expression could account in large part for the decreased chemotactic responsiveness towards C5a and LTB4 induced by LPS
Kuhn et al., Prostaglandins 1993 : Neither LPS nor UK 38,485 had any effect on LTB4 production by AM
Hoglen et al., Toxicological sciences : an official journal of the Society of Toxicology 1998 (Body Weight) : In contrast, LPS stimulated production of TNF and LTB4 was significantly decreased only in KC of LMPW fed F-344 rats