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EPHB2 — IL3

Text-mined interactions from Literome

Iida et al., Leukemia 1999 (Acute Disease...) : Three samples with N-Ras mutations were stimulated with IL-3 , GM-CSF and G-CSF separately but ERK2 activation was induced in none of these samples stimulated with these cytokines
Birkenkamp et al., Eur Cytokine Netw 1999 (Acute Disease...) : Despite the fact that IL-3 did induce p38 and ERK kinase activity, it was not able to enhance IL-6 protein secretion, which coincided with the inability of IL-3 to induce NFkappaB ( nuclear factor kappaB ) activation and IkappaB ( inhibitory protein kappaB ) degradation
Deng et al., Proc Natl Acad Sci U S A 2000 : p44MAPK/extracellular signal regulated kinase 1 ( ERK1 ) and p42 MAPK/ERK2 are activated by IL-3 , colocalize with mitochondrial Bcl2, and can directly phosphorylate Bcl2 on Ser-70 in a stauro-resistant manner both in vitro and in vivo
Valledor et al., J Biol Chem 2000 : Granulocyte/macrophage colony stimulating factor, interleukin 3, and TPA, all of which induced macrophage proliferation, also induced ERK activity, which was maximal at 5 min poststimulation ... Granulocyte/macrophage colony stimulating factor, interleukin 3 , and TPA, all of which induced macrophage proliferation, also induced ERK activity, which was maximal at 5 min poststimulation
Craddock et al., J Biol Chem 2001 : Expression of Deltap85 and incubation with LY294002 both inhibited IL-3 induced activation of Mek, Erk1 , and Erk2 ... To investigate the mechanism leading to decreased activation of Erks, we investigated effects on SHP2 and Gab2, both implicated in IL-3 regulation of Erk activation
Zirngibl et al., Mol Cell Biol 2002 : Bone marrow derived Fps/Fes-null macrophages showed no defects in granulocyte-macrophage colony stimulating factor-, interleukin 6 (IL-6)-, or IL-3 induced activation of signal transducer and activator of transcription 3 ( Stat3 ) and Stat5A or LPS induced degradation of I kappa B or activation of p38, Jnk, Erk , or Akt
Mera et al., Immunol Lett 2002 : Tyrosine phosphorylation of ERK was detected after stimulation with IL-3 or MSP, whereas treatment with U0126 specifically inhibited IL-3- or MSP induced ERK phosphorylation but not tyrosine phosphorylation of betac
Maggi et al., J Biol Chem 2003 (Cardiovirus Infections...) : ERK activation is required for double stranded RNA- and virus induced interleukin-1 expression by macrophages
Wheadon et al., Blood 2003 : We demonstrate that TEL/PDGFbetaR expression augmented IL-3 induced activation of PKB, STAT5, ERK1/2 , p38, and JNK1/2
MacGillivray et al., J Biol Chem 2003 (MAP Kinase Signaling System) : The protein tyrosine phosphatase SHP-2 regulates interleukin-1 induced ERK activation in fibroblasts
Yu et al., Oncogene 2003 : Further biochemical analyses revealed that IL-3 induced Jak/Stat, Erk , and PI3 kinase pathways in SHP-2 ( -/- ) cells were impaired and reintroduction of WT SHP-2 into mutant cells partially restored IL-3 signaling
Chang et al., J Biol Chem 2004 (Inflammation...) : The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation
Nonami et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Spred-1 negatively regulates interleukin-3 mediated ERK/mitogen activated protein ( MAP ) kinase activation in hematopoietic cells ... In IL-3 dependent Ba/F3 cells expressing c-kit, forced expression of Spred-1 resulted in a reduced proliferation rate and ERK activation in response to not only SCF but also IL-3 ... In contrast, DeltaC Spred augmented IL-3 induced cell proliferation and ERK activation ... Augmentation of ERK activation and proliferation in response to IL-3 was also observed in Spred-1-deficient bone marrow derived mast cells ... These data suggest that Spred-1 negatively regulates hematopoiesis by suppressing not only SCF induced but also IL-3 induced ERK activation
Wang et al., J Biol Chem 2005 : SHP-2 modulates interleukin-1 induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1
Nonami et al., Genes Cells 2005 : Forced expression of Cav-1 suppressed SCF- and IL-3 induced proliferation and ERK activation
Vilariño et al., J Immunol 2005 : Acute IL-3 priming up-regulates the stimulus induced Raf-1-Mek-Erk cascade independently of IL-3 induced activation of Erk ... The kinetics, dose response, and pharmacologic characteristics of the IL-3 priming of stimulus induced Erk phosphorylation support the involvement of a yet unknown mechanism that is independent of IL-3 induced Erk and PI3K activation
Miranda et al., Leuk Res 2005 (MAP Kinase Signaling System) : Additionally, interleukin-3 , which inhibits G-CSF induced differentiation of 32 Dc l3 cells, also inhibited the ability of G-CSF to stimulate prolonged MEK/ERK activation
Edmead et al., Cell Signal 2006 : Expression of DeltaPHGab-2 reduced IL-3 dependent proliferation and long-term activation of ERK1 and 2 and PKB by IL-3
Yu et al., J Biol Chem 2006 (Leukemia) : The E76K mutation in the N-terminal Src homology 2 domain increased interactions of mutant SHP-2 with Grb2, Gab2, and p85, leading to hyperactivation of IL-3 induced Erk and phosphatidylinositol 3-kinase (PI3K) pathways
Zhang et al., Blood 2007 (MAP Kinase Signaling System) : Gab2-deficient c-Kit ( + ) Lin ( - ) cells also demonstrate impaired activation of extracellular signal regulated kinase ( ERK ) and S6 in response to IL-3 , which supports defects in activating the phosphatidylinositol-3 kinase (PI-3K) and mitogen associated protein kinase ( MAPK ) signaling cascades
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Resveratrol inhibits high glucose induced PI3K/Akt/ERK dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Pecaric-Petkovic et al., Blood 2009 (Hypersensitivity) : These effects are similar to that of IL-3, but the signaling pathways engaged are distinct because IL-33 strongly activates NF-kappaB and shows a preference for p38 MAP-kinase, while IL-3 acts through Jak/Stat and preferentially activates ERK
Woolson et al., Cell Signal 2009 : Here we demonstrate that elevation of cyclic AMP ( cAMP ) levels in human umbilical vein endothelial cells ( HUVECs ) specifically attenuates ERK1,2 activation in response to either leptin or a soluble interleukin IL-6 receptor-alpha/IL-6 ( sIL-6R alpha/IL-6 ) trans signalling complex but not protein kinase C activator phorbol 12-myristate 13-acetate
Saraiva et al., Immunity 2009 : Interleukin-10 production by Th1 cells requires interleukin-12 induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
Cuong et al., Life Sci 2009 (Inflammation...) : Pre-treatment with C-K significantly inhibited zymosan mediated secretion of tumor necrosis factor-alpha, interleukin (IL)-6 , and IL-12 p40, and the activation of ERK1/2 and p38
Pradhan et al., J Biol Chem 2010 : In addition, expression of components of the interleukin-3 receptor, IL3Ra and the common beta chain, activated JAK2-V617F as well as STAT5 and ERK
Zhu et al., J Immunol 2011 (Asthma) : Earlier work has identified ERK1/2 as molecular markers for IL-5 priming, and in this article, we show that IL-3 , a member of the IL-5 family, also augments fMLP stimulated ERK1/2 phosphorylation in primary eosinophils
Nogueira-Pedro et al., J Leukoc Biol 2011 (Hyperplasia...) : In contrast, a-tocopherol enhanced ERK1/2 activation in response to IL-3 stimulation in HSC/HP cells without altering the expression of IL-3Rs
Lo et al., J Biol Chem 1998 : Requirements of focal adhesions and calcium fluxes for interleukin-1 induced ERK kinase activation and c-fos expression in fibroblasts
Egerton et al., Int Immunol 1998 : However, the production of IL-3 and IL-4 was only partially dependent upon ERK activation, whereas IL-5, IL-10, IFN-gamma and GM-CSF production was severely affected by diminished ERK activation
Barge et al., Leukemia 1998 (Leukemia, Myeloid) : In contrast, stimulation of the IL-3 receptor in AML193 cells resulted in a transient Erk activation peaking at 5 min and returning to base levels after 15 min
Pearson et al., Growth Factors 1998 : IL-3 also stimulated a transient increase in the activity of both ERK 1 and 2
Lee et al., Blood 1999 : cAMP dramatically increased ERK activity in the presence of CSF-1 or IL-3