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TIMP1 — TNF

Text-mined interactions from Literome

Watari et al., Am J Pathol 1999 : TNF-alpha increased secretion of procathepsin S, but did not affect TIMP-1 and reduced TIMP-2 production
Lee et al., Biochem Biophys Res Commun 2001 : We previously reported that tumor necrosis factor-alpha converting enzyme ( TACE ) was specifically inhibited by TIMP-3 but not TIMP-1 , -2, and -4
Lacherade et al., Am J Physiol Lung Cell Mol Physiol 2001 : In conclusion, induction by TNF-alpha of upregulation of both the 92-kDa gelatinase and its inhibitor TIMP-1 results in maintenance of the gelatinase-inhibitor balance, indicating that basement membrane degradation does not mediate the TNF-alpha induced increase in alveolar epithelial monolayer permeability
Alexander et al., Invest Ophthalmol Vis Sci 2001 : Agents that modulate protein kinase A (PKA) or inhibit phosphatidylinositol 3-kinase (PI3K) had minimal effects on trabecular MMP or TIMP induction by TNFalpha , whereas several agents that modulate PKC activity were effective
Schett et al., Arthritis Rheum 2001 (Arthritis) : These results indicate a central role of MMPs in TNFalpha mediated tissue damage in vivo and a promising therapeutic role for TIMP-1
Peng et al., Circ Res 2002 (Cardiomyopathies...) : In cultured neonatal rat cardiac fibroblasts, TNF-alpha reduced cellular [ 3H ] -proline incorporation, increased matrix metalloproteinase-2 (MMP-2) activity and protein, and increased TIMP-1 protein levels
Alexander et al., Invest Ophthalmol Vis Sci 2003 (MAP Kinase Signaling System) : The components of this MAP kinase pathway in the TM are dramatically affected by TNFalpha and inhibition of Erk 's phosphorylation blocks the changes in MMP and TIMP expression
Hirata et al., Biol Reprod 2003 : The production of TIMP-1 in BT-1 cells was also augmented by IL-1alpha, TNFalpha , and HGF at the level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate
Dasu et al., Burns Incl Therm Inj 2003 : However, TNF-alpha significantly increases TIMP-1 protein levels
Yamane et al., J Immunol 2003 (Scleroderma, Systemic) : We showed that TNF-alpha prevents TGF-beta induced gene trans activation, such as alpha2 ( I ) collagen or tissue inhibitor of metalloproteinases 1 , and TGF-beta signaling pathways, such as Smad3, c-Jun N-terminal kinase, and p38 mitogen activated protein kinases, without inducing levels of inhibitory Smad7 in human dermal fibroblasts
Hui et al., Arthritis Rheum 2003 (Osteoarthritis, Knee) : The in vivo data clearly indicated that OSM + TNFalpha overexpression increased MMP levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 )
Lévêque et al., Microbes Infect 2004 : Differential regulation of gelatinase A and B and TIMP-1 and -2 by TNFalpha and HIV virions in astrocytes
Nee et al., Kidney Int 2004 (MAP Kinase Signaling System) : Cotreatment with IL-1beta abolished the induction of MMP-9 but augmented the inhibition of TIMP-1 in the presence of TNF-alpha ... The differential effects of TNF-alpha and IL-1beta on proximal tubular MMP-9 and TIMP-1 expression are mediated through the TNF-RI, the IL-1-RI and the different signaling pathways of PKC, ERK1/2, and p38 MAPK
Tomita et al., Gut 2006 (Choline Deficiency...) : Inhibition of TNF induced TIMP-1 upregulation by TIMP-1 specific siRNA reversed the apoptotic suppression seen in hepatic stellate cells
Kralisch et al., FEBS Lett 2005 : Interestingly, TNFalpha and IL-6 induced TIMP-1 protein secretion more than 3- and 2-fold, respectively
Kato et al., Oral Dis 2006 : The mRNA expression of MMP-1 and-2 was suppressed by PHT, while TIMP-1 mRNA expression was enhanced by both TNF-alpha and PHT
MacNaul et al., J Biol Chem 1990 (Arthritis, Rheumatoid) : The results revealed that 1 ) stromelysin and collagenase were not always coordinately expressed ; 2 ) IL-1 was more potent than TNF or PMA in the induction of stromelysin expression ; 3 ) neither IL-1 nor TNF significantly affected TIMP expression ; 4 ) PMA induced both metalloproteinase and TIMP expression ; and 5 ) the combination of IL-1 plus TNF had a synergistic effect on stromelysin expression
Nee et al., Nephron. Experimental nephrology 2007 : TNF-alpha but not IL-1 beta resulted in a dose dependent increase in the latent form of MMP-9 and a decrease in TIMP-1 production ... Co-treatment with IL-1 beta had no effect on the induction of MMP-9 but increased the inhibition of TIMP-1 in the presence of TNF-alpha ... Inhibition of PKC provided evidence of the importance of this pathway in mediating the TNF-alpha induced suppression of TIMP-1 ... The cytokine TNF-alpha causes different effects on human mesangial MMP-9 and TIMP-1 expression which are mediated through the TNF-RI, and the different signalling pathways of PKC, ERK 1/2 and p38 MAPK
Nee et al., Nephron. Experimental nephrology 2008 : Therefore we examined the potential role of nitric oxide ( NO ) in the regulation of MMP-9 and TIMP-1 by tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) using the human mesangial cell line ( HMCL )
Jung et al., Cytotherapy 2011 : In addition, the levels of monocyte chemoattractant protein-1 ( MCP-1 ) and tumor necrosis factor-a (TNF-a) were decreased, and tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) and vascular endothelial growth factor ( VEGF ) levels were increased at 4 weeks in both the IM-C and IM-I groups
Ito et al., FEBS Lett 1990 : Furthermore, the fact that TNF and IL-1 differently controlled the production of TIMP suggests that the signal pathway of TNF for TIMP production is different from that of IL-1
Panagakos et al., Inflammation 1995 (Osteosarcoma) : The presence of TNF-alpha suppresses maturation induced transcription of MMP-2, enhances TIMP-1 transcription, but has little effect on MMP-9 mRNA levels
Shingu et al., Clin Exp Immunol 1993 : In addition, tumour necrosis factor-alpha (TNF-alpha) significantly inhibited and IL-6 significantly enhanced TIMP production in endothelial cells, synovial cells and chondrocytes ... These results suggest that the cytokine effects on TIMP production are different among the different cell types, and that either IL-1 beta or TNF-alpha induce cartilage matrix degradation by disrupting the collagenase/TIMP balance, while, on the other hand, IL-6 protects the tissue through an opposite effect
So et al., Nihon Sanka Fujinka Gakkai Zasshi 1993 (Chorioamnionitis...) : The results were as follows : 1 ) TNF alpha enhanced the production of MMPs and PGE2 and suppressed TIMP production
Black et al., Biochem Biophys Res Commun 1996 : A matrix metalloproteinase did process tumor necrosis factor-alpha extracted from COS cells, but neither tissue inhibitor of metalloproteinases-1 nor -2 blocked tumor necrosis factor-alpha processing by human monocytes
Alexander et al., Curr Eye Res 1998 : A phorbol mitogen ( TPA ), and TNF alpha and beta, interleukin-1 alpha and PDGF BB stimulate gelatinase B, stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression ; TIMP-2 levels are reduced by TNF but not affected by the other treatments
Lombard et al., Cancer Res 1998 (Adenocarcinoma...) : The synthetic MMPIs and TIMP-2, but not TIMP-1 , also caused a dose dependent increase in the number of TNFalpha receptors retained on the surface of Colo 205 cells, as determined by flow cytometry
Zhang et al., J Immunol 1998 : Differential regulation of monocyte matrix metalloproteinase and TIMP-1 production by TNF-alpha , granulocyte-macrophage CSF, and IL-1 beta through prostaglandin dependent and -independent mechanisms ... TNF-alpha , granulocyte-macrophage-CSF (GM-CSF), or IL-1 beta when added individually enhanced the endogenous levels of 92-kDa gelatinase ( MMP-9 ) and TIMP-1 but failed to induce interstitial collagenase ( MMP-1 ) ... Th2 cytokines, such as IL-4, inhibited the induction of MMPs and TIMP-1 by TNF-alpha , GM-CSF, and IL-1
Knittel et al., J Hepatol 1999 : In general, TNF-alpha stimulated both MMP and TIMP expression of hepatic stellate cells, while TGF-beta1 induced TIMP expression only