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RETN — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RETN → TNF (decreases)
  Evidence: above suggest that ?-agonists, insulin, TNF-?, and possibly growth hormone might mediate their insulin resistance- inducing effects at least in part via up-regulation of IL-6 expression in adipocytes.

Text-mined interactions from Literome

Li et al., Eur J Endocrinol 2003 (Insulin Resistance) : Moreover, we studied the effects of tumor necrosis factor-alpha (TNF-alpha) , a known mediator of insulin resistance, on the expression of AM and resistin in 3T3-L1 adipocytes
Lin et al., Mol Cell Endocrinol 2005 (Hyperinsulinism...) : Stimulated resistin expression in white adipose of rats with bile duct ligation induced liver cirrhosis : relationship to cirrhotic hyperinsulinemia and increased tumor necrosis factor-alpha
Yang et al., J Huazhong Univ Sci Technolog Med Sci 2005 : Effect of tumor necrosis factor-alpha on resistin expression in 3T3-L1 adipocytes and its mechanism ... In order to investigate the effect of tumor necrosis factor-alpha (TNFalpha) on resistin expression in 3T3-L1 adipocytes, and further explore its mechanisms, the differentiated 3T3-L1 adipocytes were incubated with 0, 1, 10, 100 ng/mL TNFalpha respectively for 24 h, and then the expression of resistin was determined ... It was concluded that TNFalpha could inhibit the expression of resistin in 3T3-L1 adipocytes
Muse et al., J Clin Invest 2007 (Diabetes Mellitus, Type 2...) : We also report that centrally mediated mechanisms partially control resistin induced expression of TNF-alpha , IL-6, and SOCS-3 in the liver
Wang et al., Am J Physiol Heart Circ Physiol 2007 (Mechanotransduction, Cellular) : The stretch induced resistin is mediated by TNF-alpha , at least in part, through ERK MAP kinase and NF-kappaB pathways
Juan et al., Obesity (Silver Spring) 2008 : In order to characterize the regulation of resistin gene expression, we explore the effect of tumornecrosis factor-alpha (TNF-alpha) on resistin mRNA expression and its underlying mechanism in 3T3-L1 adipocytes ... To further explore the involvement of nitric oxide ( NO ) in TNF-alpha regulated resistin expression, the effect of the NO donor, sodium nitroprusside ( SNP ), on resistin mRNA levels in adipocytes and the effect of the nitric oxide synthase (NOS) inhibitors, N ( G ) -nitro-L-arginine methyl ester ( L-NAME ), and S, S'-1,3-phenylene-bis ( 1,2-ethanediyl ) -bis-isothiourea.2HBr ( PBITU ), on the TNF-alpha effect in adipocytes were examined ... Our results showed that TNF-alpha caused a dose dependent reduction in resistin mRNA levels ... Pretreatment with L-NAME and PBITU significantly reversed the TNF-alpha induced downregulation of resistin expression, while treatment with SNP mimicked the inhibitory effect of TNF-alpha on resistin expression ... Our data suggest that TNF-alpha suppresses resistin expression by inducing iNOS expression, thus causing overproduction of NO, which downregulates resistin gene expression
Shyu et al., J Biomed Sci 2009 : TNF-alpha stimulation increased resistin protein and mRNA expression and atorvastatin inhibited the induction of resistin by TNF-alpha ... SP600125 and JNK small interfering RNA ( siRNA ) completely attenuated the resistin protein expression induced by TNF-alpha and mevalonate ... The gel shift and promoter activity assay showed that TNF-alpha increased AP-1 binding activity and resistin promoter activity, while SP600125 and atorvastatin inhibited the AP-1 binding activity and resistin promoter activity induced by TNF-alpha ... In conclusion, JNK and Rac pathway mediates the inhibitory effect of atorvastatin on resistin expression induced by TNF-alpha
Zhao et al., Zhonghua Gan Zang Bing Za Zhi 2009 (Disease Models, Animal...) : CONCLUSIONs : Resistin can induce the production of TNF alpha , IL-6 and other inflammatory factors by hepatocytes, and therefore is an important inflammatory factor in NASH