◀ Back to TNF
CNTF — TNF
Text-mined interactions from Literome
Krady et al., J Neurosci Res 2008
:
We show that
CNTF reduces COX-2 levels, whereas IL-6 increases the expression of IL-1beta,
TNFalpha , and Cox-2
Hong et al., Exp Toxicol Pathol 2008
(Pterygium) :
Expression of neurotrophic factors in human primary pterygeal tissue and selective
TNF-alpha induced stimulation of
ciliary neurotrophic factor in pterygeal fibroblasts
Benigni et al., Mol Med 1995
:
Ciliary neurotrophic factor inhibits brain and peripheral
tumor necrosis factor production and, when coadministered with its soluble receptor, protects mice from lipopolysaccharide toxicity ... Since the elevation of serum CS is an important feedback mechanism to limit the synthesis of proinflammatory cytokines, particularly tumor necrosis factor (TNF), we have investigated the
effect of
CNTF on both
TNF production and lipopolysaccharide (LPS) toxicity ... In order to measure the
effects of
CNTF on LPS induced
TNF production in the brain, mice were injected intracerebroventricularly ( i.c.v. ) with 2.5 micrograms/kg LPS ...
CNTF , administered either alone or in combination with its soluble receptor,
inhibited the induction of serum
TNF levels by LPS ... In vitro,
CNTF only marginally
affected TNF production by LPS stimulated mouse splenocytes, but it acted synergistically with dexamethasone ( DEX ) in inhibiting TNF production
Meazza et al., Neuroimmunomodulation 1997
(Edema...) :
Since
ciliary neurotrophic factor (CNTF) inhibits the production of
TNF and activates the hypothalamus-pituitary-adrenal axis ( HPAA ), we investigated whether CNTF can produce antiinflammatory actions and whether it may act through a central mechanism, using the murine air pouch model of inflammation
Demitri et al., J Inflamm 1998
(Disease Models, Animal...) :
Ciliary neurotrophic factor (CNTF) inhibits the production of
tumor necrosis factor (TNF) in lipopolysaccharide (LPS) treated mice and protects against LPS lethality when coadministered with its soluble receptor ( sCNTFR alpha )