◀ Back to RELA

DDX58 — RELA

Text-mined interactions from Literome

Chang et al., Microbes Infect 2006 : Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I dependent IRF-3 and PI3K dependent NF-kappaB activation ... Evidently, a cellular RNA helicase, retinoic acid-inducible gene I (RIG-I) , and a cellular kinase, phosphatidylinositol-3 kinase (PI3K), are required for flavivirus induced IRF-3 and NF-kappaB activation, respectively
Lin et al., J Biol Chem 2006 : In the present study, we demonstrate that the NF-kappaB-inducible, anti-apoptotic protein A20 efficiently blocks RIG-I mediated activation of NF-kappaB- , IRF-3-, and IRF-7 dependent promoters but only weakly interferes with TRIF-TLR-3 mediated IFN activation
Seth et al., Cell Res 2006 : RIG-I activates NF-kappaB and IRFs through the recently identified adaptor protein MAVS, a CARD domain containing protein that resides in the mitochondrial membrane
Liu et al., J Virol 2007 : Short interfering RNA ( siRNA ) -mediated RIG-I `` knockdown '' significantly inhibited early nuclear factor-kappaB (NF-kappaB) and interferon response factor 3 (IRF3) activation 9 h postinfection ( p.i. )
García et al., Biochim Biophys Acta 2009 (Enterovirus Infections) : PICin induced NF-kappaB and IFN-beta promoter activation were prevented by the DN-RIG-I
Samanta et al., Cancer Sci 2010 (Burkitt Lymphoma) : In BL cells, EBERs activate RIG-I signaling and induce the expression of type-I IFNs and interferon stimulated genes ( ISGs ) through the activation of RIG-I substrates, nuclear factor-kappa B (NF-kappaB) , and IFN regulatory factor 3 (IRF-3), and anti-inflamatory cytokine IL-10 through IRF-3 but not NF-kappaB signaling
Yoboua et al., J Virol 2010 : Respiratory syncytial virus mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I , TRAF6, and IKK beta