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MAPK11 — P2RX7
Text-mined interactions from Literome
Michel et al., Br J Pharmacol 2006
(Calcium Signaling) :
In this study we have further studied the
effect of
MAPK inhibitors on recombinant and native
P2X(7) receptors ... Overall, the data cast doubt on a general
role of
MAPK in mediating
P2X(7) receptor mediated changes in cellular permeability
Barbieri et al., Neurochem Int 2008
(Encephalitis...) :
In this study, we investigated whether P2X7 stimulation on cultured cortical astrocytes promoted a differential activation of mitogen activated protein kinases ( MAPKs ), and whether the second messenger arachidonic acid ( AA ), which is also a key modulator of neuroinflammation, affected the
P2X7 mediated
MAPK phosphorylation
Bianco et al., Purinergic Signal 2009
:
Furthermore,
P2X(7) receptor activation promptly
induces p38
mitogen activated protein kinase ( MAPK ) phosphorylation in cortical but not in hippocampal astrocytes
Faria et al., Naunyn Schmiedebergs Arch Pharmacol 2010
:
Our results show that PKC,
MAPK , PI3K, and cytoskeletal components are
involved in
P2X(7) receptor large-channel formation in 2BH4 cells and peritoneal macrophages
Kawano et al., Biochem Biophys Res Commun 2012
:
P2X4-knockdown cells, established by transfecting RAW264.7 cells with two short hairpin RNAs ( shRNAs ) targeting P2X4 receptor, showed a decrease of the initial peak of intracellular Ca ( 2+ ) after treatment with ATP, though pore formation and the
P2X7 mediated activation of ERK1/2 and p38
MAPK were not affected