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EPHB2 — SSTR1

Text-mined interactions from Literome

Florio et al., J Physiol Paris 2000 (MAP Kinase Signaling System) : We show that the activation of ERK via SSTR1 is mediated by the betagamma subunit of a pertussis toxin-sensitive G-protein and requires both the small G protein Ras and the serine/threonine kinase Raf-1
Barbieri et al., Am J Physiol Endocrinol Metab 2009 (Brain Neoplasms...) : In C6 rat glioma cells, somatostatin is cytostatic in vitro via phosphotyrosine phosphatase dependent inhibition of ERK1/2 activity mediated by SSTR1 , -2, and -5 ... Somatostatin and SSTR1 , -2, and -5 agonists strongly inhibited in vivo C6 tumor growth, intratumoral neovessel formation, Ki-67 expression, and ERK1/2 phosphorylation and induced upregulation of p27 ( Kip1 ), whereas only a modest activation of caspase-3 was observed
Florio et al., Mol Endocrinol 1999 : We show that the activation of ERK via SSTR1 is pertussis toxin sensitive and requires the small G protein Ras, phosphatidylinositol 3-kinase, the serine/threonine kinase Raf-1, and the protein tyrosine phosphatase SHP-2 ... The activation of ERK by SSTR1 increased the expression of the cyclin dependent protein kinase inhibitor p21 ( cip1/WAF1 )